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Hyaluronic Acid (HA)

Sodium Hyaluronate-Cosmetics grade

Sodium hyaluronate-Food grade

Sodium hyaluronate-Eye drop grade

Sodium hyaluronate-Injection grade

Sodium hyaluronate-Feedstuff grade

Hyaluronic Acid Knowledge 

Sodium Hyaluron-ate Gel
What is Hyaluronic Acid?
The Dangers of Hyaluronic Acid
Does Hyaluronic Acid Really Work?
The Multi-Faceted Benefits of Hyaluronic Acid
Steroid and Hyaluronic Acid Injections for Osteoarthritis Pain
Sodium Hyaluron-ate Gel
Sodium Hyaluron-ate Gel is used for:
Treating dry, scaly skin.
Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade Gel is a mucopolysaccharide. It works by replacing a substance found in the skin.

Do NOT use Sodium Hyaluron-ate Gel if:
you are allergic to any ingredient in Sodium Hyaluronate:cosmetics,food,eye drop,injection,feedstuff£¬ Gel
Contact your doctor or health care provider right away if any of these apply to you.

Before using Sodium Hyaluron-ate Gel:
Some medical conditions may interact with Sodium hyaluronate Gel. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
¡öif you are pregnant, planning to become pregnant, or are breast-feeding
¡öif you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
¡öif you have allergies to medicines, foods, or other substances
Some MEDICINES MAY INTERACT with Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade Gel. Because little, if any, of Sodium Hyaluron-ate Gel is absorbed into the blood, the risk of it interacting with another medicine is low.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sodium Hyaluron-ate Gel may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Sodium Hyaluron-ate Gel:
Use Sodium Hyaluron-ate Gel as directed by your doctor. Check the label on the medicine for exact dosing instructions.
¡öWash your hands before and after using Sodium Hyaluronate Gel, unless your hands are part of the treated area.
¡öApply a generous amount of medicine to the affected area and rub in well.
¡öIf you miss a dose of Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade Gel, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Sodium Hyaluron-ate Gel.

Important safety information:
¡öSodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade Gel is for external use only. Do not get Sodium Hyaluron-ate Gel in your eyes, nose, or mouth. If you get Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade Gel in your eyes, rinse with cool water right away.
¡öDo not use Sodium Hyaluron-ate Gel for other skin conditions at a later time.
¡öPREGNANCY and BREAST-FEEDING: It is unknown if Sodium Hyaluronate Gel can cause harm to the fetus. If you become pregnant while taking Sodium Hyaluron-ate Gel, discuss with your doctor the benefits and risks of using Sodium Hyaluronate :cosmetics,food,eye drop,injection,feedstuff, Gel during pregnancy. It is unknown if Sodium Hyaluron-ate Gel is excreted in breast milk. If you are or will be breast-feeding while you are using Sodium Hyaluron-ate Gel, check with your doctor to discuss the risks to your baby.
Possible side effects of Sodium Hyaluron-ate Gel:
All medicines may cause side effects, but many people have no, or minor, side effects. No COMMON side effects have been reported with Sodium Hyaluronate cosmetics,food,eye drop,injection,feedstuff, Gel. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

Proper storage of Sodium Hyaluron-ate Gel:
Store Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade,Gel at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Keep Sodium Hyaluronate Gel out of the reach of children and away from pets.

General information:
¡öIf you have any questions about Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade Gel, please talk with your doctor, pharmacist, or other health care provider.
¡öSodium Hyaluronate(Hyaluronic Acid(HA,Hyaluronan) ) Gel is to be used only by the patient for whom it is prescribed. Do not share it with other people.
¡öIf your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about Sodium Hyaluronate Gel. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider
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Steroid and Hyaluronic Acid Injections for Osteoarthritis Pain
Experts agree that the best treatment for osteoarthritis is a combination of education, lifestyle changes such as losing weight and exercising, and medication. But when the usual lifestyle strategies and pain relieving medications are not doing enough, or when side effects keep you from taking your meds, your doctor may recommend injecting medicine directly into an osteoarthritic joint.

Osteoarthritis Treatment: Steroid Injecti-ons
The medications that can be used via injection for osteoarthritis treatment are corticosteroids and hyaluronic acid (HA,Hyaluronan). "Steroid and hyaluronic acid injections(Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade) are both safe, temporary measures that provide pain relief," says Jason Koh, MD, an orthopedic surgeon at Northwestern Memorial Hospital in Chicago.

Your doctor will first numb the joint area, then put a long needle into the joint space. If there is too much fluid inside the joint, it will first be removed and then the medication will be injected into the joint. These procedures can be done right in your doctor's office and you can go home afterward. Your doctor will provide post-procedure instructions but for most people the recovery period is not difficult.

Corticosteroids are synthetic drugs that block inflammation by acting like hormones in your body. Since joint inflammation is a major cause of osteoarthritis pain, steroid injecti-ons can help for a while. The pain relief is immediate but temporary, and will gradually wear off as you begin using the joint again.

Osteoarthritis treatment with steroid injections is usually done on knee or hip joints. Inject-ions into the hip joint are harder to do, and the evidence that this osteoarthritis treatment works for the hip is not as strong as it is for the knee.

"Multiple steroid injections may weaken joint tissue, so I typically recommend no more than two to three a year, maximum. Patients have variable responses: Some get no relief; others get up to six months," notes Dr. Koh. There is also an increased chance of getting an infection in the joint after steroid osteoarthritis treatment.
Steroid inject-ions are relatively inexpensive and are covered by most insurance plans.

Osteoarthritis Treatment: Hyaluronic Acid Injection£¨Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade£©
Hyaluronan, Koh says, is an artificial form of the body's own lubricating fluid for joints: ¡°There is little risk, but three to five shots are usually required.¡± The treatment¡¯s effects usually last three to six months, he says, with about 75 to 85 percent of people experiencing significant pain relief. ¡°These can be repeated without bad effects,¡± he says, noting that Hyaluronan treatments are more expensive than steroids, but are covered by most insurance plans and Medicare if certain criteria are met.

Hyaluronan was first approved by the Food and Drug Administration for osteoarthritis treatment in 1997. A recent review of 76 clinical trials that studied hyaluronic acid (HA,Hyaluronan) inject-ions(Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff gradef)as an osteoarthritis treatment concluded that hyaluronic acid worked to relieve osteoarthritis pain as well as oral pain medications, and that the results lasted longer than steroid inject-ions for osteoarthritis treatment.

If you are still having pain despite lifestyle changes and oral medical treatment, or if you can't take oral medication because of side effects, speak to your doctor about using joint inject-ions. These osteoarthritis treatments are not a cure for the disease, but they can effectively get you through a flare-up of your osteoarthritis pain in a relatively safe manner.
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The Dangers of Hyaluronic Acid
Touted by beauty experts and the media as the "fountain of youth" (one of a plethora of anti-aging miracle ingredients marketed to the public), Hyaluronan is a naturally occurring "goo" produced in the body and distributed through connective, epithelial, and neural tissues. It acts primarily as a lubricant and cushion to protect cells. H-A(Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade) has been synthesized in laboratories and used as a main ingredient in anti-aging cosmetic products as an inject-ion or topical application. Also called Hyaluronan, this gooey substance is abundantly produced and distributed throughout the body, especially in areas where there is a connective tissue disorder.
Hyaluronic Acid(HA,Hyaluronan)  gel is sometimes injected in certain parts of the body (such as the lips, cheeks or thighs) to prevent those parts from aging. The inject-ions, which are supposed to be safe and nonallergenic, are administered by a medical expert, usually in a beauty and wellness clinic. For some people, particularly those with a low threshold for pain and those who have sensitive skin, these inject-ions can be painful and lead to redness, swelling or inflammation of the skin. Other known side effects include acne and necrosis (the premature death of cells or tissues).
Reported Side Effects
Some of the side effects reported by patients who have had hyaluronic knee inject-ions for treating Hyaluronic Acid(HA,Hyaluronan) (Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade) abnormalities include coughing, difficulty swallowing, dizziness, nausea, fever, itching, nasal congestion, and skin rashes. Some have reported pain, bruising, or swelling in the area of inject-ion while others have encountered acute headaches, diarrhea, difficulty breathing, loss of appetite and stomach ache.
Certain medications such as aspirin, NSAIDs (non-steroidal inflammatory drugs such as ibuprofen and paracetamol), St. John's Wort, and Vitamin E supplements can increase swelling and bleeding after inject-ions of Hyaluronic Acid(HA,Hyaluronan) . As a result, it is best to avoid these medications for at least a week prior to the inject-ions. A good doctor will forewarn the patient about these contraindications and the possible side effects and dangers of H-A.
HA Imbalance
Abnormal levels of Hyaluronic Acid(HA,Hyaluronan)  can occur artificially or naturally. Particularly susceptible are those with connective tissue disorders (CTDs). As with any kind of substance in the body such as hormones, proteins and nutrients, too much or too little can lead to health problems. Because of excess production, connective tissue disorders can lead to H-A abnormalities that trigger health complications. These complications include mitral valve response, keratoconus, Marfan syndrome, Ehlers-Danlos syndrome, stickler syndrome, Osteogenesis imperfecta, and osteoarthritis. High levels of Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade have also been connected to some forms of cancer. In general, healthy people have a healthy dose of Hyaluronic Acid(HA,Hyaluronan) circulating in their bodies and hardly need supplementation.
H-A abnormality is usually indicative of a connective tissue disorder and is a symptom rather than a primary medical condition. When the main problem is treated, such as osteoarthritis and muscle contractures, Hyaluronic Acid(HA,Hyaluronan) production and distribution will most likely go back to normal levels.
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The Multi-Faceted Benefits of Hyaluronic Acid
Last month, we introduced a new highly bioavailable form of Hyaluronan  that provides the most effective delivery system available for this nutrient. This month, we will focus on the many ways that this high molecular weight H-A£¨Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade£© lozenge can contribute to overall health.

H-A is ubiquitous throughout the body, the highest amounts being found in the extracellular matrix of soft connective tissues such as synovial fluid (joint lubricant), vitreous fluid in the eyes, and in the skin. It is involved in several key processes, including cell signaling, wound repair and regeneration, morphogenesis, and matrix organization.1 As a fundamental component that helps maintain cellular structure and function, Hyaluronic Acid(HA,Hyaluronan) acts as a lubricant, an antioxidant, a shock absorber during weight bearing, and a cushion to protect against physical trauma. The fact that H-A is so important in so many aspects of health makes it particularly unfortunate that the levels of Hyaluronic Acid(HA,Hyaluronan) decline with advancing age.

H-A supplementation can make up for age-related deficiencies of this nutrient. Research has shown success with Hyaluronic Acid(HA,Hyaluronan) supplementation in inflammatory processes in areas such as rheumatology, ophthalmology, dermatology, and dentistry, as described below.

Joint Protection
H-A has been used in osteoarthritis for more than 30 years. Many studies have documented the long-lasting pain-relieving effects of intra-articular supplementation with H-A in subjects with knee osteoarthritis, a procedure that was approved by the FDA in 1997.2

Oral supplementation with Hyaluronic Acid(HA,Hyaluronan)(Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade) also shows promising results as seen in a recent study. This placebo-controlled trial enrolled 20 male and female subjects aged 40 years and older with knee osteoarthritis (pain for at least 15 days in the previous month and symptoms present for at least 6 months) who were randomized to oral supplementation of Hyaluronic Acid(HA,Hyaluronan) or placebo.3 At the end of the study period, H-A-treated participants experienced a greater decrease in total symptom scores based on a standardized osteoarthritis index, compared with placebo after just 8 weeks (-18.6 vs -15.8). There was also a greater magnitude of pain relief in the H-A-treated group compared with placebo (11.1 vs. 2.2) as well as a significant improvement in physical component summary scores (6.1 vs. 3.6). The researchers also observed that the Hyaluronic Acid(HA,Hyaluronan) group needed half the amount of pain rescue medication (500 mg acetaminophen capsules) compared with the placebo group during the study. In addition, compared with placebo, more H-A subjects perceived improvement in joint pain (75 percent vs. 50 percent) and muscle aches (75 percent vs. 38 percent). The researchers concluded that oral HA ¡°was useful to enhance several markers of quality of life in adults with osteoarthritis of the knee.¡±

The impressive results seen with oral H-A(Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade) supplementation may be particularly advantageous in elderly subjects in whom osteoarthritis-related pain results in a serious limitation of activities of daily living.3 Oral supplementation also has obvious advantages over intra-articular Hyaluronic Acid(HA,Hyaluronan) by avoiding potential complications at the injection site and discomfort associated with repeated inject-ions.4

Clinical studies have confirmed anti-inflammatory, anabolic, and cartilage-protective actions of HA in reducing pain and improving patient function.5 Hyaluronic Acid(HA,Hyaluronan) appears to have a stimulatory effect on the metabolism of chondrocytes (cells found in the cartilage) through its interaction with CD44 receptors.6

Researchers have speculated this could lead to permanent improvement of cartilage with oral supplementation, which can elevate plasma Hyaluronic Acid(HA,Hyaluronan) concentrations over a long time period.3

A growing body of evidence also indicates that mitochondrial dysfunction and DNA damage play a causal role in disorders such as osteoarthritis that are linked to excessive generation of free radicals. Pretreatment of chondrocytes with Hyaluronic Acid(HA,Hyaluronan) has been shown to enhance their survival by decreasing mitochondrial damage and enhancing DNA repair capacity and cell viability, while preserving ATP levels and ameliorating apoptosis.7

Furthermore, studies have shown that the concentration and level ofHyaluronic Acid(HA,Hyaluronan)(Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade) decline significantly in inflammatory arthritis,8 which can be counteracted with high molecular weight H-A supplementation. This measure has proved effective in promoting chondrocyte Hyaluronic Acid (HA,Hyaluronan) and proteoglycan synthesis, reducing the production of substances that break down collagen such as proinflammatory mediators and enzymes called matrix metalloproteinases (MMPs), and maintaining joints in good condition.8

Temporomandibular Joint (TMJ) Syndrome
As with osteoarthritis, the level of Hyaluronic Acid(HA,Hyaluronan) is significantly lower in the synovial fluid from patients with inflammation of the temporomandibular joint, which connects the jaw to the skull.9 Hyaluronan has a natural affinity for joint tissue. In one study, the intra-articular administration of sodium hyaluron-ate into the temporomandibular joint in patients with Wilkes stage II disease (a classification used to define TMJ severity according to 5 stages) showed better efficacy in reducing pain and improving joint function compared with the oral administration of pain-relief tablets.10

Promoting Healthy Skin
In 2003, the FDA approved hyaluronic acid injections £¨Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade£© for filling soft tissue defects such as facial wrinkles. Hyaluronic Acid (HA,Hyaluronan) and collagen are both vital components of skin tissue. However, there is a progressive reduction in the number of hyaluro-nic acid granules in human skin, deteriorating to a complete absence in individuals over 60. It is believed these variations account for the decreased turgidity, wrinkled appearance, and altered elasticity of skin tissue.11 The regulation of major skin cells known as fibroblasts is central to both healing and scarring processes. Laboratory studies show that supplementing fibroblasts with Hyaluronic Acid(HA,Hyaluronan)£¨Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade£© causes a significant increase in their ability to renew skin tissue, resulting in increased proliferation within the collagen matrix.12

The anti-inflammatory effects of H-A also carry important implications for collagen regeneration in maintaining healthy skin. The cutaneous benefits of H-A can be seen in studies where it has been shown to block IL-1b, a cytokine that inhibits collagen biosynthesis at the transcriptional level.13 IL-1 also inhibits the expression of insulin-like growth factor-1, a highly potent stimulator of collagen synthesis, while Hyaluronic Acid(HA,Hyaluronan) counteracts this process.14 H-A also suppresses MMP-1, which preferentially breaks down major components of collagen in the skin,15 and reduces levels of an inflammatory chemokine called RANTES. Both processes are mediated partly by the interaction of H-A(Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade) with its receptor called CD4416 that is found in abundance in the oral mucosa, making the use of an Hyaluronic Acid(HA,Hyaluronan) lozenge particularly useful for maintaining healthy skin..

The effectiveness of H-A also extends to skin disorders such as oral lichen planus (OLP), a common inflammatory disease of the skin and mouth. In a study of 124 patients with oral lichen planus, HA significantly reduced soreness scores compared with placebo for up to 4 hours.17 Patients treated for up to 28 days with Hyaluronic Acid (HA,Hyaluronan) showed a significant reduction in the size of the erosive/ulcerated area compared with baseline. The researchers concluded that HA may be a ¡°useful addition to the treatment option for OLP.¡±

In the above study, Hyaluronic Acid(HA,Hyaluronan£¬Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade) was used in direct contact with the mucus membranes. A 30 mg lozenge provides an ideal delivery system for this type of use since it delivers more H-A for equal or longer periods of time to target tissues.

Managing Ocular Health
Another important body system where Hyaluronic Acid (HA,Hyaluronan) distribution declines dramatically with aging is in human eye tissue.18 Researchers have speculated that this decline may play a role in age-related ocular disorders.18

UV light is the most common cause of radiation injury to the eye. While the cornea absorbs most UVB light to protect the inner eye, exceeded threshold levels induce corneal inflammation (photokeratitis). UVB light also triggers different signaling cascades that cause apoptosis of corneal cells. However, researchers have recently shown for the first time that high molecular weight H-A protects human corneal epithelial cells against UVB-induced apoptosis as well as decreasing UVB-induced release of the proinflammatory mediators IL-6 and IL-8.19 Corneal cells express CD44 receptors on their plasmic membranes, which is a specific point of interaction for Hyaluronic Acid(HA,Hyaluronan). It is believed that this may be a key factor in understanding how H-A protects against UVB radiation.19 H-A£¨Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade£© supplementation can also be useful to people with dry eyes as well as people suffering eye discomfort after computer use.20-22

Maintaining a Healthy Oral Cavity
Another emerging benefit for the use of Hyaluronic Acid(HA,Hyaluronan) is in the treatment of plaque-induced gingivitis. H-A has shown anti-inflammatory and antibacterial effects in both gingivitis and periodontitis. It is important to remember that oral disease processes contribute to cardiovascular disease and total inflammatory burden in the body, including elevated C-reactive protein, and the condition of the mouth and gums is therefore important to overall health. Due to its tissue-healing properties, H-A may be a useful adjunct in diseases of the oral cavity.23-24 The availability of Hyaluronic Acid(HA,Hyaluronan£¬Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade) in a lozenge preparation, which is well absorbed across the oral mucosa, enhances its effectiveness for optimizing dental hygiene.

H-A has also been shown to be of benefit in recurrent aphthous ulcers, or canker sores, which are painful open sores inside the mouth or upper throat caused by breaks in the mucous membrane.25 In addition, in vivo studies show that sodium hyaluron-ate effectively accelerates the healing process after tooth extraction by stimulating the expression of bone-forming proteins.26

Another oral condition that may cause difficulties in speech and eating as well as increasing the susceptibility of periodontal tissue to infection is known as xerostomia, or dry mouth, which is a common complaint in the elderly. Elderly patients with dry mouth, not caused by any history of connective tissue disease, have been shown to have lower Hyaluronic Acid(HA,Hyaluronan) levels in their saliva compared with age-matched controls.27 Oral use of Hyaluronan improved hyposalivation and unpleasant oral complaints associated with dry mouth.28

H-A is a vital component of cellular structure and offers a multitude of benefits including anti-inflammatory and antioxidant effects, pain-relief, joint lubrication and cartilage-protection, collagen regeneration, and enhancement of cell viability. Most of these actions are mediated via the H-A-specific CD44 receptor present on endothelial, epithelial, and smooth muscle cell membranes. Since H-A declines naturally with age, oral H-A£¨Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade£© supplementation with a new lozenge offers an efficient alternative, which is well absorbed through the highly vascularized oral mucosa that is rich in CD44 receptors. As a result, oral HA supplementation offers an effective solution for joint protection, maintaining healthy skin and eyes, and is a useful adjunct for good dental hygiene.
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What is Hyaluronic Acid?
Hyaluronan is a type of polysaccharide called a glycosaminoglycan. Also known as hyaluronan or hyaluron-ate, Hyaluronan occurs naturally in the human body and is central to regulating cell growth and renewal. In fact, it is found extensively in connective, epithelial, and neural cells. As such, Hyaluronan has found its way into many skin care products, particularly anti-wrinkle formulations. In addition, it has been credited with extending life in those who consume copious amounts in the diet, resulting in the media dubbing Hyaluronan as the ¡®key to the fountain of youth.¡¯

The fact that this acid binds with water accounts for the special interest in this substance in dermatology. When injected under the skin, it provides an appearance of fullness at the site, smoothing out fine lines and wrinkles for up to six months. Administration of this cosmetic procedure is available in the form of Restylane®, a non-animal stabilized source of Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade that is produced from bacteria. In addition to being a corrective procedure for moderate to heavy wrinkling of facial skin, it is a popular lip augmentation treatment.

As a skin care procedure, hyaluronic acid injections (Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade) present certain side effects for some individuals. Temporary bruising, swelling, and redness at the inject-ion site are fairly common. However, subjects undergoing therapy with nonsteroidal anti-inflammatory drugs, or who supplement with vitamin E or St. John¡¯s Wort, are advised to stop taking these medications at least one week prior to receiving these acid inject-ions because of an increased risk of bleeding.

Ironically, while this acid may be touted as a beauty enhancer, it can also diminish the appearance of skin and even cause tissue damage. This is because Hyaluronan readily degrades in the presence of at least seven enzymes classified as hyaluronidases. Degradation of hyaluronan is significantly accelerated when the skin is exposed to high levels of ultraviolet rays (UVs) from the sun. As a result, both the acid and its by-products are sometimes responsible for promoting inflammatory response and even tumor cell proliferation. In fact, hyaluronan levels are sometimes used as a biomarker for prostate and breast cancers. However, since Hyaluronic Acid(HA,Hyaluronan) plays a key role in tissue repair, it has solid application in several medical treatments. For instance, it has been used extensively to speed healing after ophthalmic procedures, such as corneal transplantation, and surgery to correct retinal detachment and glaucoma. Hyaluronic acid injection therapy is also used as a treatment for osteoarthritis of the knee, ankle, and shoulder.
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Does Hyaluronic Acid Really Work?
What is Hyaluro-nic Acid?
In healthy young skin, as that which is seen in babies and young children, Hyaluronic Acid(HA,Hyaluronan) is found in abundance. A naturally occurring substance made by the body, Hyaluronan is also known as glycosaminoglycan (GAG) and can be found throughout the connective tissue of the body. As the years go by and the human body begins to age, the production of HA begins to decrease. Individuals who smoke or otherwise have an unhealthy lifestyle may see the effects of lower H-A levels more quickly than those who maintain an active and healthy diet and lifestyle.

Can Hyaluronic Acid Supplementation fight wrinkles?
The result of declining Hyaluronic Acid(HA,Hyaluronan) levels initiates a simultaneous reduction in the amount of water that can be held by the cells of the connective tissue. When the connective tissue becomes dehydrate several problems begin to occur. First, wrinkles and fine lines make their appearance on the surface of the skin. Second, the skin begins to take on a brittle, dry look. And, third, the occurrence of cellulite increases as the connective tissue weakens and is no longer able to hold the cellulite of the female body in its place. The cellulite bubbles up to the surface of the skin and the familiar bumps, lumps and cottage cheese looking skin appears.
Some studies show that Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade taken as a supplement cannot be absorbed by the body. Other studies declare injecti-ons of H-A as the most efficient means to deliver additional H-A to connective tissue. Topical applications of H-A, as in the case of moisturizers, are a popular method of adding HA to the skin surface. Topical use of H-A tends to hydrate the top layer of skin, the epidermis, resulting in smoother, softer skin, by trapping moisture below the surface.

Hyaluronic Acid Alternatives
An alternative option to increase Hyaluronic Acid(HA,Hyaluronan) levels in the body is to supplement with an H-A precursor. Glucosamine is needed to make H-A and can be added to the diet as a routine supplement as a capsule, powder or tablet. The cascade of steps when glucosamine is added to the diet is an increase in the body¡¯s production of HA(Sodium hyaluronate:cosmetics grade,food grade,eye drop grade,injection grade,feedstuff grade), an increase in water content inside the connective tissue and surrounding areas, and an overall decrease in wrinkles, lines and cellulite.
As a side note, almost 90% of glucosamine is absorbed by the intestines making supplements an easy method to increase the substance in the body. Additionally, glucosamine supplements leading to increased Hyaluro-nic acid production in the body are now being used quite regularly for patients suffering from osteoarthritis.
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