Sodium Hyaluronate(Eye drops grade)|Sodium Hyaluronate for Eye drop grade

The Story of the Hyaluronic Acid Molecule

Why Most Hyaluronic Acid Topical Products Are a TRAP!

Beneficial actions of exogenous hyaluronic acid on wound healing

Sodium hyaluronate for Eye drop grade

Sodium Hyaluronate(Eye drops grade)

Hyaluronic Acid can improve the ocular bioavailability of the drug by increasing the viscosity of solution and prolonging the time of the drug in the eye, relieve drug stimulation, increase eye drops lubrication and comfort. Hyaluro-nic Acid has excellent biotolerability with ocular tissue, and can be used in many kinds of eye drops.

Technical standard:

Specification\Name	Sodium hyaluronate ( Eye drop grade )
Characters	White hygroscopic powder or granule
Sodium Hyaluronate (dry basis)	90%-105%
Glucuronic acid	≥45.0%
PH(0.1% Water Solution)	6.0-7.5
Molecular Weight	(0.8-2.0)*10⁶
Intrinsic viscosity	≥1600（on the dries basis ）
Residue on Ignition	≤20%
Protein	≤0.1%
Transparency (0.1% Solution)	≥98%
Loss on drying	≤8.0%
Heavy metals (as Pb)	≤ 20ppm
Arsenic	≤2ppm
Bacteria Endotoxin	≤0.5 EU/mg
Hemolysis	Negative
Viable Hemolytical Streptococci	Negative
Bacteria count	≤10CFU/g
Mold & Yeast	≤10CFU/g
Pseudomonas aeruginosa	Negative
Staphylococcus aureus	Negative
Packing	According to the request of the customers
Storage	Stored in an airtight container at 2-8 ^oC
Validity	Two years

Sodium Hyaluronan

What is sodium hyaluronate(Eye drops grade) ?
Sodium hyaluronate(Eye drops grade) is similar to the synovial (sin-OH-vee-ul) fluid that surrounds your joints. Synovial fluid acts as a lubricant and shock absorber.

Sodium Hyaluronate(Eye drops grade)（Sodium Hyaluronate for Eye drop grade） is injected into the knee joint to treat pain caused by osteoarthritis. This medication is usually reserved for people whose pain has not been relieved by using other medicines or treatments.

Sodium Hyaluronate(Eye drops grade)（Sodium Hyaluronate for Eye drop grade） may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about sodium hyaluronate(Eye drops grade)?
You should not receive Sodium Hyaluronate(Eye drops grade)（Sodium Hyaluronate for Eye drop grade） if you have an infection of your knee joint, or infection of the skin around your knee.
Before receiving sodium hyaluronate(Eye drops grade), tell your doctor if you have an allergy to eggs, birds, or bird products.
Sodium Hyaluronan is given as an injection into your knee. This medicine is usually given as one injection per week for a total of 3 weeks.
For the first 48 hours after your injection, avoid any strenuous or weight-bearing activity that lasts longer than 1 hour. This includes jogging, tennis, stair-climbing, or lifting weights. Follow your doctor's instructions about other activity restrictions.
What should I discuss with my health care provider before receiving sodium hyaluronate(Eye drops grade)?
You should not receive sodium Hyaluronan if you have:
■an infection of your knee joint; or
■infection of the skin around your knee.

Before receiving sodium Hyaluronan, tell your doctor if you have an allergy to eggs, birds, or bird products.

This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether sodium Hyaluronan passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How is sodium hyaluronate(Eye drops grade) given?
Sodium Hyaluronate(Eye drops grade)（Sodium Hyaluronate for Eye drop grade） is given as an injection into your knee. You will receive this injection in a doctor's office or other clinic setting.

This medicine is usually given as one injection per week for a total of 3 weeks. Your doctor may want you to have injections more often than once each week.

What happens if I miss a dose?
Contact your doctor for instructions if you miss an appointment for your injection.

What happens if I overdose?
Seek emergency medical attention if you think you have received too much of this medicine. An overdose of sodium Hyaluronan is not expected to produce life-threatening symptoms.

What should I avoid while receiving sodium hyaluronate(Eye drops grade)?
For the first 48 hours after your injection, avoid any strenuous or weight-bearing activity that lasts longer than 1 hour. This includes jogging, tennis, stair-climbing, or lifting weights. Follow your doctor's instructions about other activity restrictions.
Sodium hyaluronate(Eye drops grade) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Other less serious side effects are more likely to occur, such as:
■pain or swelling where the medicine was injected;
■joint pain;
■headache;
■numbness or tingly feeing;
■skin irritation; or
■knee pain or tenderness.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Artilcle Source:

http://www.drugs.com/mtm/sodium-hyaluronate-injectable.html

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The Story of the Hyaluronic Acid Molecule

What is Hyaluro-nic Acid?
Hyaluro-nic acid(Sodium Hyaluronate(Eye drops grade),Sodium Hyaluronate for Eye drop grade) is a carbohydrate, more specifically a mucopolysaccharide occurring naturally throughout the human body. It can be several thousands of sugars (carbohydrates) long. When not bound to other molecules, it binds to water giving it a stiff viscous quality similar to “Jello”. This viscous Gel is one of the most heavily researched substances in medicine today with thousands of clinical trials mostly in the fields of orthopedics and eye surgery. Its function in the body is, amongst other things, to bind water and to lubricate movable parts of the body, such as joints and muscles. Its consistency and tissue-friendliness allows it to be used in skin-care products as an excellent moisturizer. Hyaluro-nic acid (Sodium Hyaluronate(Eye drops grade),Sodium Hyaluronate for Eye drop grade) is one of the most hydrophilic (water-loving) molecules in nature and can be described as "nature's moisturizer".

What is its Chemical Structure?
It is naturally produced in the human body and is chemically classified as a Glycosaminoglycan. In the body, hyaluro-nic acid always presents itself as a large high molecular weight molecule. The molecule is made up of a repetitive sequence of two modified simple sugars, one called glucuronic acid and the other N acetyl glucosamine. These compounds are both negatively charged and when put together, they repel producing an exceptionally long stretched out molecule (high molecular weight). H-A molecules that are long and large in size produce a high viscosity (lubrication) effect which resists compression and allows our joints and skin to bear weight, withstand tension and endure abuses, such as physical trauma and abrasion that no other tissue in the body could withstand.

When was Hyaluro-nic Acid discovered?
Hyaluro-nic acid was first used commercially in 1942 when Endre Balazs applied for a patent to use it as a substitute for egg white in bakery products. The discovery of Hyaluro-nic Acid(Sodium Hyaluronate(Eye drops grade),Sodium Hyaluronate for Eye drop grade) was very unique. No other molecule had ever been discovered that has such unique properties to the human body. Balazs went on to become the leading expert on H-A, and made the majority of discoveries concerning HA.

Where is it located in the body?
Hyaluro-nic Acid is found naturally in most every cell in the body and occurs in high concentrations in specific body locations. In each body location, it serves a different function. Unfortunately, HA (Sodium Hyaluronate for Eye drop grade) also has a half-life ( the time it takes for the molecule to get broken down and excreted from the body) of less than 3 days and possibly even as little as one day in the skin. For this reason, it is imperative that the body continually replenish itself with H-A. Below are some of the areas in the human body where hyaluro-nic acid is present and critical to its function.

Bones/Cartilage
Hyaluronic Acid (Sodium Hyaluronate for Eye drop grade) is found in all bones and cartilage structures throughout the body. Both of these structures provide a resilient rigidity to the structure of the human body. H-A is especially found in various forms of cartilage but none more than the hyaline cartilage. As you've probably guessed it, hyaline is short for hyaluro-nic acid. Hyaline cartilage covers the ends of the long bones where articulation (bending) occurs and provides a cushioning effect for the bones. The hyaline cartilage has been called the "gristle cartilage" because its resistance to wear and tear. Hyaline cartilage also supports the tip of the nose, connects the ribs to the sternum and forms most of the larynx and supporting cartilage of the trachea and bronchial tubes in the lungs.

Synovial fluid
Our joints (like the elbows and knees) are surrounded by a membrane called the synovial membrane which forms a capsule around the ends of the two articulating bones. This membrane secretes a liquid called the synovial fluid. Synovial fluid is a viscous fluid with the consistency of motor oil. It has many functions, but none more than providing the elastic shock absorbing properties of the joint. Its second most important function in the joint is to carry nutrients to the cartilage and to also remove waste from the joint capsule. Normally these processes are carried out via the blood vessels but because cartilage is without blood flow (avascular) the body relies on the Hyaluro-nic Acid to do so.

Tendons and Ligaments/Connective tissue
Connective tissue is found everywhere in the body. It does much more than connect body parts; it has many forms and functions. Its major functions include binding, support, protection, and insulation. One such example of connective tissue is the cordlike structures that connect muscle to bone (tendons) and bone to bone (ligaments). In all connective tissue there are three structural elements. They are ground substance , stretchy fibers (collagen and elastin) and a fundamental cell type. Whereas all other primary tissues in the body are composed mainly of living cells, connective tissues are composed largely of a nonliving ground substance which separates and cushions the living cells of the connective tissue. The separation and cushioning allow the tissue to bear weight, withstand great tension and endure abuses that no other body tissue could. All of this is made possible because of the presence of the H-A and its ability to form the gelatinous ground substance fluid.

Scalp Tissue and Hair Follicles
Structurally the scalp is identical to the skin tissue located throughout the body except it also contains about 100,000 hair follicles that give rise to hair. Actually the hair and the hair follicle are a derivative of skin tissue. There are two distinctive skin layers, one, the epidermis (outer layer) which gives rise to the protective shield of the body and the other, the dermal layer (deep layer) which makes up the bulk of the skin and is where the hair follicle is located. This dermal layer is composed of connective tissue and the connective tissue, with its gelatinous fluid like characteristics provides support, nourishes and hydrates the deep layers of the scalp. The result is healthy lustrous hair and a moisturized scalp. Again, all of this is made possible because of the presence of H-A(Sodium Hyaluronate(Eye drops grade)Sodium Hyaluronate for Eye drop grade) in the scalp tissue and its ability to form this fluid and hold water.
■Lips
The lips are a core of skeletal muscle covered by skin tissue. The dermal layer of the lips is composed primarily of connective tissue and its components hyaluro-nic acid and collagen that give the structure (shape) and plumpness to the lips. The hyaluro-nic acid binds to water creating a gelatinous fluid that hydrates the surrounding tissue and keeps the collagen (responsible for keeping the skin tight) nourished and healthy. The result is healthy well hydrated and plump lips that are well protected from the environment.
■Eyes
Hyaluro-nic acid is highly concentrated inside the eyeball. The fluid inside the eye called the vitreous humor is composed almost completely of hyaluro-nic acid. The H-A gives the fluid inside the eye a viscous gel like property. This gel acts as a shock absorber for the eye and also serves to transport nutrients into the eye. Eye surgeons inject H-A directly into the eye to help maintain the shape of the eye during surgery. It has been said that after the 5th decade of life, our eyes stop producing the much needed hyaluronic acid (Sodium Hyaluronate(Eye drops grade)（Sodium Hyaluronate for Eye drop grade）) resulting in various eye problems such as poor vision, dry eyes, and floaters.
■Gum Tissue
The Gums (gingivoe) are composed of dense fibrous connective tissue (ligaments) which secure the teeth to the aveloar bone (jaw bone). Once again, connective tissue is composed of a fibrous tissue surrounded by hyaluro-nic acid (extra-cellular matrix). Without the hyaluro-nic acid, the gum tissue becomes unhealthy and may lead to swelling. If the HA is present it helps to provide the tensile strength of the ligaments that secure the tooth in place by providing hydration and nourishment. The result is a healthy set of gums.
■Skin
Although Hyaluro-nic Acid (Sodium Hyaluronate(Eye drops grade)（Sodium Hyaluronate for Eye drop grade）) can be found naturally in most every cell in the body, it is found in the greatest concentrations in the skin tissue. Almost 50% of the bodies HA is found here. It is found in both the deep underlying dermal areas as well as the visible epidermal top layers. Young skin is smooth and elastic and contains large amounts of H-A that helps keep the skin stay young and healthy. The H-A provides continuous moisture to the skin by binding up to 1000 times its weight in water. With age, the ability of the skin to produce H-A decreases leaving the skin unhealthy and wrinkled.
■ECM (ground substance)
The extracellular matrix (ECM) is a gelatinous (gel-like) fluid that surrounds almost all living cells and is essential to life. It gives structure and support to the body and without it, we would just be a trillions cells without a shape or function. It is essentially the mortar between the bricks. The skin, bones, cartilage, tendons and ligaments are examples where the ECM is located in the body. The ECM is composed of material (fibrous elements) called elastin and collagen surrounded by a gelatinous substance. HA's roles in the ECM is to prevent the stretchy fibers in the body from overstret ching and drying out by continually bathing them in this nutritious water base gelatinous fluid. It also serves as a wonderful medium through which nutrients and waste are transported to and from the cells of these structures. This fluid would not exist if it was not for the ability of the H-A molecule to bind up to 1000 times its weight in water.

How does Hyaluro-nic Acid help the body?
In the joints If we compare the joints of the human body to and automobile engine, the joint fluid in the body mimics the oil in a car engine. At regular intervals we replace the oil in our car engines because the heat and friction breakdown the oils viscosity. The oil becomes thinner and less able to protect the metal surfaces from excessive wear. Hyaluro-nic acid acts the same way in our joints. As we age the viscosity of the joint fluid breaks down and becomes thin and is unable to cushion the joint cartilage. This leads to increased friction and wear on the cartilage surfaces of the joints. Hyaluro-nic Acid helps to restore the normal viscosity of joint fluid and to prevent further damage to the joint.

In the skin
The skin is the largest organ in the body comprising about 15% of the body weight. Roughly 50% of the Hyaluronic Acid (Sodium Hyaluronate for Eye drop grade) in our body is found in the skin. Hyaluro-nic Acid and Collagen are vital to maintaining the skin’s layers and structure. It is the collagen that gives the skin its firmness but it is the H-A that nourishes and hydrates the collagen. Imagine the collagen as the stretchy fibers that restore the skin back to shape when stretched. Collagen is like a rubber band but stretch that rubber band a million times, like what we do with our skin and without any moisture. Eventually that rubber band gets overstretched (saggy) and dried out and will most likely break. This is much the same way the collagen in our skin reacts leaving our skin dry and wrinkled. Now imagine that same rubber band stretched a million times while under water the whole time. Chances of that rubber band drying out and breaking are minimal. Consider the Hyaluro-nic Acid as the water that keeps the collagen moist and elastic. Collagen is continuously surrounded and nourished by the gelatinous H-A substance. Young skin is smooth and highly elastic because it contains high concentrations of Hyaluro-nic Acid (Sodium Hyaluronate(Eye drops grade),Sodium Hyaluronate for Eye drop grade), which helps skin stay healthy. As we grow older, the body loses its ability to maintain this same concentration in the skin. With decreasing levels of H-A in the skin, so goes the ability of the skin to hold water. The result, the skin becomes drier and loses its ability to restore itself. Hyaluro-nic acid acts as a space filler by binding to water and thus keeping the skin wrinkle-free.

Conclusion
Hyaluro-nic acid is essential for the health of the synovial fluid which lubricates the bones and joints. Hyaluronic acid is essential for the structure of the extracellular matrix in the skin which gives the skin a youthful wrinkle free appearance. Hyaluro-nic Acid is an essential component of the vitreous humor (fluid of the eye) which is essential for proper eye health and function. Hyaluro-nic Acid supports and gives structure to healthy skin, scalp, gums and lips by assisting with maintaining the nourishment and hydration of the epidermal and dermal layers of each structure. Hyaluro-nic Acid, a key factor to maintaining healthy strong tendons and ligaments by providing nourishment, waste removal and hydration to these structures. Hyaluro-nic Acid is essential to building healthy strong cartilage all the way from the heart valves to the cartilage surrounding the ends of joint bones. Supplementation with hyaluro-nic acid is crucial due to decreased synthesis or production of hyaluro-nic acid that occurs with aging and chronic injury.

Article Source:

http://www.spirited-lady-boutique.com/hyaluronicacid.html

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Beneficial actions of exogenous hyaluronic acid on wound healing

To determine the effect of exogenous hyaluro-nic acid on healing of experimental wounds, responses in the hamster cheek pouch were measured after a hole was cut through the tissue with a biopsy punch. Fluorescence-labeled dextran was administered intravenously as a macromolecular tracer and the microcirculation was observed in vivo with a fluorescence microscope connected to a high-resolution television system. In one group a gelatin sponge soaked in 1.5 ml 16 mg/dl HA (Sodium Hyaluronate for Eye drop grade) in water was applied topically at the time of injury and on postinjury days 1, 3, 5, and 7. The control group received the sponge soaked in the aqueous vehicle. Every 2 days after injury, the microcirculation was observed or histologic specimens were harvested. Wound size decreased almost twice as fast with H-A compared with its vehicle (p less than 0.05). Healing was defined as time for total wound closure with at least one microvessel bridging the site of injury and required 16 or more days with vehicle but averaged less than 9 days with H-A. Early during healing the repair site was surrounded by widespread extravasation of the fluorescent tracer, an index of inflammation; this area was reduced by two thirds 2 to 4 days after injury with H-A compared with its vehicle (p less than 0.05). The density of perfused microvessels was twofold higher with H-A 2 to 4 days after injury (p less than 0.05). However, microvessel density was similar in both groups by 6 days after injury and remained similar for at least 45 days after injury, which suggests that H-A evoked no unusual angiogenic response. Histologic examination of fixed, stained specimens showed increases in intravascular leukocytes after injury and treatment-related differences in the distribution of intravascular leukocytes in 20 to 40 microns and 40 to 80 microns diameter microvessels 1 to 2 days after injury. Otherwise, leukocyte infiltration during healing was similar in both groups. The mechanism for the beneficial action of H-A on healing is unknown. However, several in vitro studies suggest that H-A is part of a feedback loop that promotes cell proliferation and migration in actively growing tissues. Alternatively, the role of H-A in water homeostasis could favor tissue hydration, which has a well-known beneficial effect on healing.

Article Source:

http://www.ncbi.nlm.nih.gov/pubmed/1984639

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Benefits of Hyaluronic Acid for Eyes

Hyaluro-nic acid is a naturally occurring component in the human body which is responsible for lubricating and cushioning. Hyaluro-nic acid, which is manufactured as an anti-wrinkle product, has been shown to have above-average moisturizing properties which aid in preventing and treating wrinkles.
Function
Hyaluro-nic acid is important as it pertains to cellular function and lubrication. As people age, the production of hyaluro-nic acid declines. When this decline begins in the aging process, it is typical to see more wrinkles appear on the skin.
Effects
A hyaluronic acid (Sodium Hyaluronate for Eye drop grade) injection is used today as an anti-wrinkle treatment, as it has the ability to work as a wrinkle filler and skin plumper. Those who have the injections as well as those who use facial creams and gels containing hyaluro-nic acid have seen drastic effects including smoother, plumper skin with an improvement in the appearance of wrinkles.
Types
Hyaluro-nic acid comes in the form of injections (Restylane and Juvederm) as well as countless creams and gels which are applied topically to the skin. While the injections are done by a physician or other qualified professional, the topical applications of hyaluronic acid are easily purchased over the counter.
Warning
Some products containing hyaluro-nic acid have been shown to have side effects such as lumps under the skin where the products was used (most commonly with the injections). Speak with your doctor about the possibility of side effects before making the decision to use these products.
Benefits
If you have wrinkles around the eye area that you would like to fill in, a product with hyaluro-nic acid may be a good choice. The key benefits of hyaluronic acid(Sodium Hyaluronate(Eye drops grade)，Sodium Hyaluronate for Eye drop grade) for the eye area is smoother, softer skin which is well-moisturized, and a decrease in the appearance of existing wrinkles

Article Source:

http://www.ehow.com/facts_5030760_benefits-hyaluronic-acid-eyes.html

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Benefits of Hyaluronic Acid

Hyaluro-nic acid naturally occurs in the body, assisting with the cushioning of joints and connective tissues. When there is a lack of hyaluro-nic acid in the body, a variety of health problems can occur.
Cell Migration
Hyaluronic acid protects cells and helps them move through the body. This is particularly useful in terms of white-blood cells, which results in a boost to the immune system.
Bodily Activity
Hyaluro-nic acid is necessary for cushioning joints and muscle contraction. When joints and muscles have plenty of hyaluro-nic acid, they function more effectively, which supports an active lifestyle.
Vision
Hyaluronic acid is present within the eyes. When there is insufficient hyaluro-nic acid（Sodium Hyaluronate(Eye drops grade),Sodium Hyaluronate for Eye drop grade）, glaucoma, corneal disease and detached retinas may occur.
Skin
Hyaluro-nic acid assists the body with healing wounds, preventing scarring and reducing wrinkles. Because of this quality (and because of how it affects bodily mobility and vision), hyaluro-nic acid is touted for its anti-aging benefits.
Sources
Though hyaluro-nic acid is naturally produced in the body, sometimes there is not enough, and health problems can result. Soy, foods rich in magnesium (such as leafy-green vegetables) and foods rich in zinc (which can be found in pumpkin seeds) are all good choices for increasing the amount of hyaluro-nic acid in the body.

Article Source:

http://www.ehow.com/facts_5465046_benefits-hyaluronic-acid.html

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Why Most Hyaluronic Acid Topical Products Are a TRAP!

Will hyaluronic acid (Sodium Hyaluronate for Eye drop grade) topical products actually end your aging misery? Well, I guess it depends. Using products that actually increase the amount of hyaluro-nic acid in your skin can certainly help smooth out wrinkles and fine lines; but products that actually contain H-A as an ingredient are a whole different story....

The introduction of hyaluro-nic acid topical products was just like when collagen products hit the market. Because of all the hype and buzz of collagen protein and it's importance in determining the firmness and elasticity of the skin (which is absolutely true), people just assumed that creams and lotions containing collagen were the answers they were looking for. But the lack of results these products produced took most consumers by surprise.

The problem is both collagen and H-A molecules are too large to penetrate through the skin. And even though collagen molecules are larger, H-A in high concentrations is thick, sticky, and almost gummy, which makes it even more difficult to be absorbed into the skin. In the end, a significant amount of these molecules are left to sit on your skin until they are washed off.

But even though these kind of hyaluronic acid（Sodium Hyaluronate(Eye drops grade)，Sodium Hyaluronate for Eye drop grade） topical products are less effective than originally thought, it doesn't mean that you cannot increase the amount of H-A in your skin. Not at all....

The hyaluro-nic acid topical products that DO WORK are those that help to NATURALLY PRESERVE the amounts of H-A that's already in all of your skin's cells. This is done by addressing the problem of H-A degradation at it's source.

You see, free radicals (which are created in the skin thanks to UV radiation, pollution, and the natural aging process) decrease the skin's ability to produce H-A naturally, and even speed up the process of it's degradation. This is because free radicals trigger the activity of a bodily enzyme called hyaluronidase. This enzymes main function is to break down H-A in your skin cells.

So the hyaluro-nic acid topical products you want to use will contain ingredients like Phytessence Wakame, which inhibits the activity of this enzyme, preserving the amounts of your natural H-A in your skin. Plus, potent antioxidants like CoenzymeQ10, manuka honey, and natural vitamin E can significantly decrease the amount of free radicals in your skin, allowing it to stay firmer, more supple, and youthful much longer.

DON'T MAKE THE SAME MISTAKE MOST CONSUMER MAKE. Instead of just buying a hyaluro-nic acid（Sodium Hyaluronate(Eye drops grade)，Sodium Hyaluronate for Eye drop grade） topical product that actually contains H-A as an ingredient, get anti-aging products that address the whole problem in a more natural and holistic way. Trust me- since I've been using these kind of products, it's been a whole lot more enjoyable looking in the mirror each and every morning without seeing wrinkles and fine lines on my skin!

You can learn more about Phytessence Wakame and the hyaluro-nic acid topical products I use that contain it, as well as other natural substances that prolong the effects that aging has on your skin by visiting my website listed below.

Article Source:

http://ezinearticles.com/?Why-Most-Hyaluronic-Acid-Topical-Products-Are-a-TRAP!&id=2065425

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