Sodium hyaluronate|Sodium Hyaluronate feedstuff grade|Sodium Hyaluronate for feedstuff grade

Hyaluronic Acid: Nature’s Hidden Beauty Secret

Understanding the Ingredients in Skin Care Products

Hyaluronic acid for skin hydration and possibly a lot more

Hyaluronic acid in latest skin care and make-up developments

Hyaluronic Acid Moisturizers. What Are They, (And What Do They Do?)

Hyaluronic acid injections (supplements) and arthroscopy could boost meniscal tear treatment

Sodium Hyaluronate for Feedstuff grade

(Sodium Hyaluronate feedstuff grade,,Sodium hyaluronate (Injection grade))

Technical standard:

Specification\Name	Sodium hyaluronate (Injection grade)
Characters	White or almost white powder
Sodium hyaluronate(dry basis)	95.0-105.0%
600nm （ 1→300 ）	≤ 0.01
260nm （ 1→300 ）	≤ 0.5
pH(0.1% Water Solution)	5.0-8.5
Transparency (0.1% Solution)	≥ 99%
Loss on drying	≤10.0%
Protein	≤ 0.1%
Heavy metals (as Pb)	≤ 20ppm
Chlorides	≤ 0.5%
Intrinsic viscosity	Practical value
Iron	≤ 80ppm
Bacteria count	≤ 10CFU/g
Bacteria Endotoxin	≤0.05 EU/mg
Packing	According to the request of the customers
Storage	Stored in an airtight container at 2-8 ^oC
Validity	Two years

Hyaluronic acid for skin hydration and possibly a lot more

Hyaluronic acid (Sodium Hyaluronate feedstuff grade,Sodium Hyaluronate for feedstuff grade) is a biopolymer naturally occurring is the skin and other tissues. It is an important component of the skin matrix. HA is also a popular skin care ingredient often used topically. To learn what this underappreciated biopolymer is all about we strongly recommend starting with our introductory article on H-A. Here we focus on possible skin benefits and limitations of topical hyaluro-nic acid.

Moisturizing effects of hyaluronic acid
Hyaluro-nic acid(Sodium Hyaluronate feedstuff grade,Sodium Hyaluronate for feedstuff grade) is highly effective humectant, i.e. an ingredient that holds moisture. H-A can hold hundreds of times its weight in water and is often used in moisturizing formulas. Indeed it can provide effective skin surface hydration, either alone or in combination with other moisturizing ingredients.

However, there is a controversy whether concentrated HA formulas should be used as a moisturizer in dry climate. When air humidity is very low, H-A may preferentially pull water from the skin rather than from the air, thus producing the opposite effect. The optimal use of H-A as a moisturizer needs further research. Until then, when trying out H-A-based products, it is prudent to be watchful for such an effect, especially in very dry environments. If proper skin hydration is not achieved, you can try adjusting H-A concentration and/or combine your H-A-based formulation with other skin care products. If you are using a commercial H-A product, you can dilute it with a compatible neutral base and/or co-apply with a compatible hydrating product (e.g. a colloidal oatmeal-based moisturizer, such as Aveeno). If you need additional flexibility regarding the concentration of H-A and/or combining it with other ingredients, you can easily make an H-A-based formulation yourself (see DIY Anti-Aging Skin Care Infopack for practical directions).

Skin irritation and inflammation
Hyaluronic acid(Sodium Hyaluronate feedstuff grade,Sodium Hyaluronate for feedstuff grade) is a polymer and the size of its molecules (chains) may vary in a wide range. Depending on the size, H-A chains may produce different physiological effects. In particular, relatively large H-A chains (molecular weight 500,000 Da or more) appear to reduce inflammatory response. There is some evidence that topically applied H-A can reduce skin irritation from various causes (such as retinoids, laser treatments, chemical peels and others). Unfortunately, as of the time of this writing, very few studies investigated H-A as a topical anti-irritant. Further research is required to determine optimal H-A concentrations and usage patterns for specific conditions. (The concentrations studied so far ranged from 0.1% to 2.5%.)

Actinic keratoses
Actinic keratoses (AKs, solar keratoses) are premalignant inflammatory skin lesions particularly common in fair skinned people who had substantial cumulative sun exposure. In several studies, a topical formula with 2.5% H-A and 3% diclofenac (a non-steroidal anti-inflammatory drug) produced marked improvement or complete clearance of AK lesions in at least half of the patients after 90 days. HA alone also produced improvement in some patients but overall was less effective than the combination.

Wrinkles
The content of hyaluronic acid (Sodium Hyaluronate feedstuff grade,Sodium Hyaluronate for feedstuff grade) in the skin matrix decreases with age, which may contribute to the development of fine lines, wrinkles and other signs of aging. Hence there is a considerable enthusiasm in the media about topical H-A as a potential wrinkle cure. At present, such hopes appear exaggerated at best. H-A variants typically used in skin care have relatively long chains (molecular weight 500,000 Da or more) and seem unlikely to penetrate the skin well enough to affect dermal matrix. A small size variant of H-A (5,000 - 20,000 Daltons) may penetrate better but there is a catch. Small size H-A appears to promote certain inflammatory responses, i.e. in that regard it has the opposite effect to large size H-A, which is anti-inflammatory. Therefore, even if small size H-A can penetrate the skin, it may not be a good skin rejuvenation agent. (To learn more, see our our introductory article on H-A.) More research is needed to determine whether any form of topical H-A is useful in treating fine line and wrinkles.

Bottom line
Hyaluro-nic acid (Sodium Hyaluronate feedstuff grade,Sodium Hyaluronate for feedstuff grade) is a natural biopolymer that can be very effective for skin hydration and moisturizing if used properly. Preliminary evidence suggests that large size H-A may also help combat skin irritation and inflammation. The effectiveness of topical H-A for wrinkles is unproven.

There are many commercially available products that contain hyaluro-nic acid. Unfortunately, most are relatively expensive (at least compared to the cost of ingredients) and may not contain H-A concentrations that fit your needs. If you cannot find a H-A-based product optimal for your skin, you can relatively easily make one yourself. For practical direction on making your own skincare formulations, including those with hyaluro-nic acid, see DIY Anti-Aging Skin Care Infopack.

Article Source:

http://www.smartskincare.com/treatments/topical/hyaluronic-acid.html

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Hyaluronic acid in latest skin care and make-up developments

Hyaluro-nic acid(Sodium Hyaluronate feedstuff grade,Sodium Hyaluronate for feedstuff grade) is a kind of muccopolysaccharide naturally present in the human body, in synovial fluid (present in joints), the umbilical cord, the eyes' vitrous humor, fetal skin and in the deeper layers of skin. Hyaluro-nic acid is a polyanionic polysaccharide that consists of N-acetyl-d-glucosamine and beta-glucoronic acid. It is also known under the name glycosaminoglycan. Hyaluro-nic acid is able to hold more water than any other natural substance, and makes gels with water. It is obtained through two different industrial methods: Extracted from cockscombs, after grinding, chemical treatment and purification. Now more often obtained by bacterial fermentation: Resulted hyaluro-nic acid fibers are obtained by genetical modified bacteria. The gel has unique viscoelastic properties and its viscosity depends on the length (molecular weight) of fibers. n the derma of the skin, hyaluro-nic acid is one of the three crucial skin components along with collagen and elastin. It is a binding agent and a structure skin stabilizer, by holding together collagen and elastin. It plays a protective role for the skin as a shock-absorbing agent and it plays a defending role against threats and bacterial infections. Its natural hygroscopic properties hold water in the skin which makes it a well known moisturizing agent. As one of the main composants of the extracellular matrix, it is also known for helping the proliferation and migration of the cells (lubricated agent).

The level of hyaluro-nic acid decreases in the skin with age, this correlates with the appearance of wrinkles. Having been approved by the FDA as a skin filler since a few years now, it is used in dermatologic Hyaluronic Acid(Sodium Hyaluronate feedstuff grade,Sodium Hyaluronate for feedstuff grade) to plump skin or lips to reduce wrinkles and fine lines.

Skin care products with hyaluro-nic acid are most frequently used to treat wrinkled skin and as a moisturizing agent. Hyaluro-nic acid is touted for its ability to "reverse" or stop aging. It is sometimes named the "key to the fountain of youth.".

Article Source:

http://www.specialchem4cosmetics.com/services/formulation-analysis.aspx?id=487

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Hyaluronic acid injections (supplements) and arthroscopy could boost meniscal tear treatment

Sodium Hyaluronate feedstuff grade,Sodium Hyaluronate for feedstuff grade

Arthroscopic surgery coupled with hyaluronic acid injections(supplements) for patients suffering from osteoarthritis and meniscal tears could help to reduce pain, it has been claimed.

According to research published on Ortho Supersite, supplementing total knee arthroscopy with the drug treatment has a beneficial effect when it comes to reducing pain and increasing range of motion postoperatively.

Geoffrey Westrich, lead author of the study, told the website: "In the patient group with meniscus tears and mechanical symptoms in which some early arthritis is present, surgeons should consider the addition of a viscoelastic supplement intraoperatively and postoperatively."

He added that the supplement could "assist patients with their recovery and hopefully mitigate some of the symptoms associated with arthritis"..

The study looked at 46 patients with early-onset osteoarthritis and a symptomatic meniscal tears.

The group was split in two and while both underwent arthroscopy, only one was treated with hyaluronic acid （Sodium Hyaluronate feedstuff grade,Sodium Hyaluronate for feedstuff grade）.

Recent research published in Arthritis Research and Therapy showed that intra- articular hyaluronic acid injections(supplements) for osteoarthritis sufferers are both safe and effective.

Article Source:

http://www.biometeurope.fr/medhome-uk/dn/medical/newsdir/Hyaluronic%20acid%20injections%20and%20arthroscopy%20could%20boost%20meniscal%20tear%20treatment/newsdirend/357&

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Hyaluronic Acid Moisturizers. What Are They, (And What Do They Do?)

Do Hyaluronic Moisturizers work?
Hyaluro-nic acid moisturizers have become popular over recent years. But do hyaluronic acid （Sodium Hyaluronate feedstuff grade，Sodium Hyaluronate for feedstuff grade,Sodium hyaluronate (Injection grade)） moisturizers really work, and if not can you get the benefits of hyaluro-nic acid to your skin some other way?

Hyaluro-nic acid (which can also be called Hyaluronan) is an important component of your skin, where it acts as a connective tissue, and it is also found to varying degrees in other parts of the body. Along with collagen and elastin it has an important role in maintaining skin health and elasticity.

Hyaluronan（Sodium Hyaluronate feedstuff grade,Sodium Hyaluronate for feedstuff grade） helps the skin retain water, being hygroscopic, thereby obviously aiding in maintaining skin hydration. It will absorb around 1000 times it’s own weight in water. This ability to retain moisture also helps keep the collagen and elastin in your skin moist which keeps the skin looking more supple and youthful.

Studies over the last few years have shown that those people who have a naturally higher intake of hyaluro-nic acid in our diets seem to age, or appear to age slower, and it is theorized that it is the higher levels of hyaluro-nic acid that are responsible for this. It has a significant role in skin elasticity in tissue repair.

There’s even been a documentary that has called hyaluronic acid(Sodium Hyaluronate feedstuff grade,Sodium Hyaluronate for feedstuff grade) be “key to the fountain of youth” for these reasons.

For this reason hyaluronic moisturizers are becoming more popular, on the presumption that if you include hyaluro-nic acid in a moisturizer you will improve the levels of hyaluronan in the skin merely by applying the moisturizer. This would seem to make sense..

However the obvious is not necessarily a correct conclusion. For example there are some doubts about whether some forms of hyaluro-nic acid included in moisturizers will successfully penetrate the skin. HA used in moisturizers generally comes from the eyes of cattle, the combs of cock birds and even from human placentas.

Although it is not entirely clear it would seem that some H-A used in moisturizers has a molecule size which is effectively too large to enter the skin, and that for this reason, although increasing the levels of hyaluro-nic acid in the skin is good for the skin, doing so by means of this form of hyaluro-nic acid moisturizer is ineffective.

There is an alternative. Rather than attempting to add the stores of HA in the skin it may well be better to prevent destruction of HA（Sodium hyaluronate (Injection grade),Sodium Hyaluronate feedstuff grade。Sodium Hyaluronate for feedstuff grade,Sodium hyaluronate (Injection grade)） in the skin, thereby preserving what is there already.

There is an enzyme in the skin called hyaluronidase. Hyaluronidase breaks down hyaluro-nic acid in the skin, and so therefore reduces the amount of H-A in the skin. So if you’re able to reduce the capacity of hyaluronidase to break down the H-A you are effectively increasing your skin’s supplies of H-A（Sodium Hyaluronate feedstuff grade,Sodium Hyaluronate for feedstuff grade）.

There is a seaweed found around the coast of Japan called Phytessence Wakame. Phytessence Wakame is a large part of the Japanese diet and it is thought that this is one of the major reasons why the Japanese have such wonderful skin right into old age. Research has now shown that Phytessence Wakame helps limit the actions of hyaluronidase, thereby helping your skin maintain its existing stores of hyaluro-nic acid.

It is now possible to get high quality natural skin care products that contain Phytessence Wakame, and which therefore help the skin retain the skin healing properties of hyaluro-nic acid.

The company that makes these excellent natural skin care products does not make a hyaluro-nic acid moisturizer, in fact it does not make any moisturizer at all, because it includes Phytessence Wakame, along with some other excellent natural ingredients, in its entire range of skin care products, thereby eliminating the need for a dedicated moisturizer.

All skin care products from this company moisturize extremely effectively. And they give their customers a money back guarantee. That’s putting your money where your mouth is.

It is entirely possible to buy hyaluro-nic acid moisturizers. More doubtful is whether or not they are effective at delivering the hyaluronic acid （Sodium Hyaluronate feedstuff grade,Sodium Hyaluronate for feedstuff grade） into the dermis of the skin. There is no doubt that increasing the stores of H-A in the skin is of great benefit to skin health, but it’s a matter of how to do that.

Using natural skin care products containing Phytessence Wakame eliminates the problem found with a hyaluronidase moisturizer that may fail to deliver the HA into the skin.

Article Source:

http://restoremyskin.com/hyaluronic-acid-moisturizer/

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Nature’s Hidden Beauty Secret

When it comes to outward signs of aging, there’s no shortage of theories about the causes. In recent years, several beauty products containing hyaluro-nic aci have been introduced into the market, ranging from vitamin supplements to Hyaluronic Acid(Hyaluronan)injections(supplements). However, most people are looking for better ways of keeping a youthful appearance without invasive procedures.

So what is Hyaluronic Acid Exactly?
Beauty is not just skin deep; in fact, the health and beauty of your hair, skin and nails is directly affected by the nutrients that you provide your body with internally and externally. One of these exciting nourishing ingredients is called hyaluronic acid（Sodium Hyaluronate feedstuff grade,Sodium Hyaluronate for feedstuff grade）. H-A is capable of holding 1,000 times its weight in water. Since it is one of the most hydrophilic (water-absorbing) molecules in nature, HA is often described as ‘nature’s moisturizer,’ providing the body with essential moisture and a viable way to erase wrinkles.

Hyaluro-nic acid is a key component of our collagen structure, including the joints, skin, veins and eyes. Hyaluro-nic acid’s lubrication abilities have made it one of the best anti-aging beauty secrets available on the market today. HA’s major role in the skin is to help regulate moisture levels by absorbing water and slowly releasing it as the cells in the skin become dehydrated. By drawing in and holding onto water in the outer cell layers, HA（Sodium Hyaluronate feedstuff grade,Sodium Hyaluronate for feedstuff grade） enables effective skin hydration, delivery of nutrients and removal of toxins. Without an adequate amount of H-A, nutrients cannot be moved into skin cells and waste cannot be eliminated from cells. When HA is taken as a supplement, it moisturizes from the the deepest layers of the skin to the outer layer, helping to maintain smooth, elastic skin.

Science and Hyaluronic Acid
Hyaluro-nic acid supports healthy skin, as noted in a study published by the Journal of Cellular Physiology in 1998. The study showed that H-A helped reproduce healthy skin cells. But as we age, the H-A content of the skin changes due to two separate clinically proven factors: the body decreases the amount of H-A it produces and begins to distribute it differently. So instead of the deepest layers sending H-A to the surface layers of the skin, it reverses, making skin look dehydrated and wrinkly.

Supplementation is one of the key factors in counteracting the body’s inability to produce HA. This new scientific evidence is paving the road for hyaluronic acid （Sodium Hyaluronate feedstuff grade,Sodium Hyaluronate for feedstuff grade） and other important nutrients like grape seed extract, Lutein and Lycopene to become the skin care of the future. Studies show benefits from oral supplementation within one to three months. In fact, the ABC program 20/20 aired a special on the small village in Japan known as Yuzuri Hara, where 10 percent of the population is 85 and older. The show attributed the people’s lack of cancer and heart disease, as well as their increased longevity, to a key component of their diet: Hyaluro-nic acid.

Hyaluro-nic acid is a naturally occurring protein in the body. It has been used orally with no adverse reaction and incredible results. There is considerable evidence that the loss of H-A is directly involved in the acceleration of aging. Nutritional supplementation of H-A(Sodium Hyaluronate feedstuff grade,Sodium Hyaluronate for feedstuff grade) is an excellent way to help support and protect your body from the negative affects of aging. This ‘internal cosmetic’ breakthrough is allowing more and more people to feel younger and healthier as they age.

Article Source:

http://www.wellsphere.com/healthy-living-article/hyaluronic-acid-nature-s-hidden-beauty-secret/883242

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Understanding the Ingredients in Skin Care Products

The information in this document will help you understand the latest ingredients in skin care products that may benefit your skin.

Use this information to sort through various skin care products on the market. If you’re still unsure which skin care products are right for you, ask your dermatologist or consult with a skin esthetician at your local salon or beauty counter.

Alpha-hydroxy acids (AHAs)
Over-the-counter skin care products containing alpha-hydroxy acids (glycolic, lactic, tartaric and citric acids) have become increasingly popular over the last five years. In the U.S. alone, there are over 200 manufacturers of skin care products that contain alpha-hydroxy acids. Creams and lotions with alpha-hydroxy acids may help with fine lines, irregular pigmentation and age spots, and may help decrease enlarged pores. Side effects of alpha-hydroxy acids include mild irritation and sun sensitivity. For that reason, sunscreen also should be used every morning. To help avoid skin irritation with alpha-hydroxy acids, it is advisable to start with a product with concentrations of AHA(Sodium Hyaluronate feedstuff grade,Sodium Hyaluronate for feedstuff grade) of 10 to 15 percent. Also, make sure you ease into it. You want to get your skin used to alpha-hydroxy acids, so you should only initially apply the skin care product every other day, gradually working up to daily application.

Beta-hydroxy acid (salicylic acid)
Salicylic acid also has been studied for its effect on skin that has aged prematurely due to exposure to ultraviolet rays from the sun. It exfoliates skin and can improve the texture and color of the skin. It penetrates oil-laden hair follicle openings and, as a result, also helps with acne. There are many skin care products available that contain salicylic acid. Some are available over-the-counter and others require a doctor's prescription. Studies have shown that salicylic acid is less irritating than skin care products containing alpha-hydroxy acids, while providing similar improvement in skin texture and color.

Hydroquinone
Skin care products containing hydroquinone are popularly referred to as bleaching creams or lightening agents. These skin care products are used to lighten hyperpigmentation, such as age spots and dark spots related to pregnancy or hormone therapy (melasma or chloasma). Some over-the-counter skin care products contain hydroquinone, but your doctor can also prescribe a solution with a higher concentration of hydroquinone if your skin doesn’t respond to over-the-counter treatments. If you are allergic to hydroquinones, you can use products containing kojic acid instead.

Kojic Acid
Kojic acid is a more recent remedy for the treatment of pigment problems and age spots. Discovered in 1989, kojic acid has a similar effect as hydroquinone. Kojic acid is derived from a fungus, and studies have shown that it is effective as a lightening agent, inhibiting production of melanin (brown pigment).

Retinol
This is a derivative of vitamin A, and you will see that a lot of skin care products contain retinol. Retinol’s stronger counterpart is tretinoin, which is the active ingredient in Retin-A and Renova. If your skin is too sensitive to use Retin-A, retinol is an excellent alternative. Here’s why skin responds to skin care products with retinol: vitamin A has a molecular structure that’s tiny enough to get into the lower layers of skin, where it finds collagen and elastin. Retinol is proven to improve mottled pigmentation, fine lines and wrinkles, skin texture, skin tone and color, and your skin’s hydration levels. You may also hear about retinyl palmitate. This falls into the same family as retinol, but if the skin care product you choose contains retinyl palmitate, you will need to use more of this product than one that contains retinol to get the same effect.

L-Ascorbic Acid
This is the only form of vitamin C that you should look for in your skin care products. There are many skin care products on the market today that boast vitamin C derivatives as an ingredient (magnesium ascorbyl phosphate or ascorbyl palmitate, for example), but L-ascorbic acid is the only useful form of vitamin C in skin care products. Vitamin C is the only antioxidant that is proven to stimulate the synthesis of collagen as well, which is essential since your body’s natural collagen production decreases as you age. Sun exposure will also accelerate the decrease in collagen. Studies have shown that vitamin C helps to minimize fine lines, scars, and wrinkles.

Hyaluronic Acid (Sodium Hyaluronate feedstuff grade,Sodium Hyaluronate for feedstuff grade)
Skin care products containing this substance are often used in conjunction with vitamin C products to assist in effective penetration. Hyaluro-nic acid (also known as a glycosaminoglycan) is often touted for its ability to "reverse" or stop aging. In news reports, you might have heard of hyaluro-nic acid as the "key to the fountain of youth." This is because the substance occurs naturally (and quite abundantly) in humans and animals, and is found in young skin, other tissues, and joint fluid. Hyaluro-nic acid is a component of the body’s connective tissues, and is known to cushion and lubricate. As you age, however, the forces of nature destroy hyaluronic acid(Sodium Hyaluronate feedstuff grade,Sodium Hyaluronate for feedstuff grade). Diet and smoking can also affect your body’s level of hyaluro-nic acid over time. Skin care products with hyaluro-nic acid are most frequently used to treat wrinkled skin.

Copper Peptide
Copper peptide is often referred to as the most effective skin regeneration product, even though it’s only been on the market since 1997. Here’s why: Studies have shown that copper peptide promotes collagen and elastin production, and also acts as an antioxidant. It also promotes production of glycosaminoglycans (think hyaluronic acid （Sodium Hyaluronate feedstuff grade,Sodium Hyaluronate for feedstuff grade）, as an example). Studies have also shown that copper-dependent enzymes increase the benefits of the body’s natural tissue building processes. The substance helps to firm, smooth, and soften skin, doing it in less time than most other anti-aging skin care products. Clinical studies have found that copper peptides also remove damaged collagen and elastin from the skin and scar tissue because they activate the skin’s system responsible for those functions.

Alpha-Lipoic Acid
You may have heard of alpha-lipoic acid as "the miracle in a jar" for its anti-aging effects. It’s a newer, ultra-potent antioxidant that helps fight future skin damage and helps repair past damage. Alpha-lipoic acid has been referred to as a "universal antioxidant" because it’s soluble in both water and oil, which permits its entrance to all parts of the cell. Due to this quality, it is believed that alpha-lipoic acid can provide the greatest protection against damaging free radicals when compared with other antioxidants. Alpha-lipoic acid diminishes fine lines, gives skin a healthy glow, and boosts levels of other antioxidants, such as vitamin C.

DMAE (dimethylaminoethanol)
If you’ve heard of fish referred to as brain food, you can thank DMAE. This substance is naturally produced in the brain, but DMAE is also present in anchovies, salmon and sardines, boosting the production of acetylcholine, which is important for proper mental functions. DMAE in skin care products shows remarkable effects when applied topically to skin, resulting in the reduction of fine lines and wrinkles.

Article Source:

http://my.clevelandclinic.org/hic_understanding_the_ingredients_in_skin_care_products.aspx

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