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Hyaluronic
Acid Knowledge |
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Sodium hyaluronate |
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Application
Category |
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Sodium Hyaluronate (Cosmetics,Eye drop,Injection,Feedstuff) Food Grade
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The physiological function of
HA in skin
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Hyaluronate in joint
physiological function |
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The source and the use
present situation of the HA |
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Application
Category |
Hyaluric acid - aging wrinkle
ultimate murderer
The Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) is human body corium layer one
ingredient, has the adsorption moisture ability, the
component reaches as high as its itself weight 1000
times, the use includes the hyaluric acid the maintenance, may improve dry and the
reduced flesh wrinkle appearance, therefore, the hyaluric acid is the improvement does and gets older the
flesh the most ideal product.Pours into corium layer of
the skin the Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate), may cause wrinkle of the
production to level rapidly, has repairs the face the
effect. Hyaluric acid - slow-down arthritis ache good
medicine---Explanation
The Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate,Sodium Hyaluronate
(Cosmetics,Eye drop,Injection,Feedstuff) Food Grade), one kind especially pure, the
macromolecular weight, the high viscosity, implant in
the ticulare using the injection hyaluric acid, can
alleviate the osseous arthritis (Osteoarthritis) the
ache, and increases the joint the mobility and the
movement energy.Injects the hyaluric acid in the
ticulare, may induce and restore the synovial fluid (Synovial
fluid) the elasticity and the viscosity.
The hyaluric acid - reduces the
ophthalmology department surgery risky security secret
recipe---Explanation
The most ideal eye surgical operation mounts the ball
liquid medicine is does with the Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate,Sodium
Hyaluronate (Cosmetics,Eye drop,Injection,Feedstuff)
Food Grade) may
support stickiness liquid, the macromolecular weight,
the high viscosity Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate)
available at cataract
surgery, in the eye corneal tranplant and glaucoma
surgery, uses for to maintain the eye the shape and the
protection valuables organization, causes the surgery
injury to fall lowly to.
The hyaluric acid - guards
against best moistens mounts (Anti-Adhesion) the medical
thing---Explanation
Moistens mounts will be the organization surface which
the thready dialysis will be normal should separate
mounts.The patient 93% can have the technique
approximately after the abdominal cavity surgery in to
moisten mounts, serious when creates the small intestine
to tie a knot.Moves in the gynecology department surgery
patient to have the formation which above 80% has
moistens mounts, but this kind of phenomenon possibly
causes the woman sterile, therefore will use
anti-moistens mounts the piece to be possible to
prevent.
Coating agent
(Coating)---Explanation
the Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) coating agent spreads in the blood
drive pipe, directs on the drive pipe and other medicine
tool has decreases the frictional force the function,
may let the blood drive pipe extremely easily direct the
vascular system, reduces the damage and the attrition.
Eye drops (Eye
Drops)---Explanation
Includes the Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) eye drops available to
protect, the lubrication and the moist eye, because
because treats the patient the eye too to do or the
adverse circumstance causes ill and other ache universal
eye disease.
Veterinarian pharmacy
(Veterinary---Explanation
May treat the horse racing and other animal common
osseous arthritis and the ache using the injection
macromolecular weight hyaluric acid way.
Wound cicatrization surgical
dressing (Wound healing dressing---Explanation
The Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) may promote already the clear sore
wound cicatrization speed, and reduces the scar the
production; Pointed out according to the report research
that, after the baby wound repair and maintenance not
easy to have the scar reason, continues for its in vivo
to include massive Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate,Sodium
Hyaluronate (Cosmetics,Eye drop,Injection,Feedstuff)
Food Grade), but the adult wound lacks,
therefore produces the scar; If uses the Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) surgical
dressing to be possible effective to prevent the scar production.In addition,
Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) also may accelerate repair
and maintenance of function the wound, therefore may use
sickness of in the wound not easy cicatrization, for
example diabetes patients and so on foot ulcer or
bedsore.
Hyaluric acid - other medicine
application---Explanation
The medicine delivers (Drug delivery): The Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate)
adds on the basic growth hormone several formulas to be
possible to promote the bone fracture the de-emphasis,
the recent test result proved the Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate,Sodium
Hyaluronate (Cosmetics,Eye drop,Injection,Feedstuff)
Food Grade) gathers
carbohydrate possibly to be possible lowly to suppress
some kind of cancer cell the expansion, this gathers
carbohydrate to mount lowly blocks in the cell surface
in the cell surface itself hyaluric acid acceptor.This
cell surface itself Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate,Sodium
Hyaluronate (Cosmetics,Eye drop,Injection,Feedstuff)
Food Grade) acceptor is the
important pipeline which the cancer cell grows |
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Hyaluronate in joint
physiological function |
(1)
Lubrication and cushion stress
Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) has the special rheology nature, most
meaningful is entrusts with the synovial fluid
non-Newtonian fluid the characteristic and the
viscoelasticity.When the joint is in the low hit
frequency (for example walks normally when), the
synovial fluid assumes the coherent solution, to in the
joint synovial membrane organization, each organization
plane, the ligament and the collagen structure and so on
exercises the lubrication function, reduces the
organization the friction; When the joint is in the high
hit frequency, the synovial fluid transforms by the
coherent characteristic into the elastic characteristic,
the cushion stress to the joint hit; When the joint
carries a heavy load, in the synovial fluid low
molecular solute and the moisture content press out from
the synovial fluid to the cartilage matrix in, causes
the synovial fluid transformation has several micron
thickness gelatinous states, transforms by the fluid
into the elastomer, acts as slow in the joint gap dies,
reduces the pressure which the joint withstands, to the
articular cartilage display protective function, also
has the protective function to in the cell and the cell
membrane receptor.Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) and the protein form
the compound cover forms thin indefinite form structure
level (laminasplenden) in the articular cartilage
surface, thickness is 1~10 ¦Ìm, along with plants is
different with the age and is different.This structure
has the very strong deformability and the elasticity,
may play glide level (slidinglayer) and the absorption
stress role, when the joint stress has the glide, this
structure may be before the cartilage surface layer to
destroy, has the buffer type function, thus display
protection cartilage, merit and so on maintenance
cartilage matrix integrity
(2) Acts as the auxiliaries and
with the proliferation barrier
Occurs when the embryonic period body, the ticulare
formation is depends on partial
Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) the
synthesis to increase, hold certain gap completes.In the
normal condition, the joint needs Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) the flowing to
maintain the ticulare being open for business.The
ticulare volume size and periphery organizes the housing
the fluid static forcing and the osmotic pressure
decided, because Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) itself is the result of the osmotic
pressure as well as took the proliferation barrier, may
adjust other macro-molecule material the transportation,
thus adjustable fluid static forcing and speed of flow,
therefore plays the decision role to the ticulare volume
size.
Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) forms the macro-molecule network
structure sufficiently in the synovial fluid density,
adjusts saving water and the macro-molecule material
proliferation, acts as a proliferation barrier in the
joint, the regulative moisture content and other
nutrition ingredient turnover cartilage matrix.The
cartilage nutrition is provides by the synovial fluid in
nutrition ingredient after the indefinite form structure
proliferation to the cartilage surface for it, but under
the cartilage the bone does not have the nutrition
function to the cartilage.The cartilage cell metabolite
and the excreta must penetrate richly including the
Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) cartilage matrix, the cartilage surface
indefinite form level proliferation to the synovial
fluid, again from the synovial fluid seepage to the
synovial membrane, in process synovial membrane
intercellular space H-A, finally converges in the synovial membrane the capillary vessel to arrive the
lymph system to drain, in this process, Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) adjusts
various material the proliferation speed, thus it can be
seen Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) the vital role which displays to
the cartilage nutrition and metabolism.
Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) to the bacterium, the toxin, the
immunity compound and so on the barrier function,
protects the cartilage and the synovial membrane exempts
the enzyme, the chemical substance as well as the toxin
and so on the destruction, stable cell membrane,
deactivated cell membrane receptor sensitivity.
(3)Street sweeper function
Discovers Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) from the 20th century 40's to
be possible by many kinds of degeneration and so on
oxidized system as well as ion radiation.Discovered
through several dozens years research that, causes the
Hyaluro-nic Acid chain to have the break cause is the
free radical, mainly for hydroxyl free radical.Through
with the free radical response, Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) may
become the elimination free radical in vivo the street sweeper.To the joint disease pathology research
discovery, the free radical which the oxygen grows
(oxygen-derivedfreeradicals, ODFR) is the initiation and
the participation pathological change important
attribute.According to the material reported that, ODFR
may contract in the organization to the knot many
macro-molecule material react, creates the organization
to damage.In the joint ODFR to the synovial fluid in as
well as constitution cartilage PGA the
skeleton Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) react, also has the destructive
effect to in the cartilage protein polyose and the
collagen textile fiber.
Has conducted many research to ODFR to the cartilage
cell function.Discoveries and so on Vincent, ODFR may
suppress the cartilage cell the growth, also the
suppression intensity has the dosage
dependence.Discoveries and so on Larsen, ODFR has the
destructive effect to the cartilage cell membrane.The
cartilage cell exposes in H2O2, may cause the cartilage
cell certain enzymes to have the active change, the ATP
content reduces obviously. Kvam and so on carries on in
vitro experiment discovered, when the cartilage cell
processes 16h with ODFR, may destroy the cartilage cell
the membrane integrity, but high Mr or
the Hyaluro-nic Acid ester derivative may protect the
cartilage cell to exempt the ODFR harm.Discoveries and
so on Sato, RA and the OA patient synovial fluid
elimination oxygen free radical ability enhancement, in
synovial fluid has the elimination oxygen
free radical, protects the cartilage the function.
Some researchers believed that,
Hyaluronic Acid (HA,Hyaluronan,Sodium Hyaluronate)
is
possibly helpful in joint fast metabolism to the cell
fragment elimination, the cell fragment may insert Hyaluronic Acid in the macro-molecule network structure,
eliminates along with the Hyaluro-nic Acid metabolism.
(4) Pair of cell function
control action
Hyaluro-nic Acid through exercises it with in the matrix
and the cell membrane Hyaluro-nic Acid union protein
react to the cell regulative function.The
density and Mr are affect to the cell
function important attribute.The high potency, high
Mr suppress the blood capillary the
production, but low Mr may induce the
blood vessel production.Some people believed that, under
the normal condition, in the ticulare the non-blood
vessel production is because its contains highly
concentrated, high Mr Hyaluro-nic Acid (Hyaluronan) the inhibitory
action result which produces to the blood vessel.
In the specific situation, the lymphocyte as well as
other many kinds of cell membrane may express the H-A
union protein (acceptor), has the pathological change
when the joint, the cell can have the change to the
Hyaluronic Acid £¨Hyaluronan£© acceptor expression, but
Hyaluronic
Acid(HA,Hyaluronan,Sodium Hyaluronate) may take advantage of this affects the cell assembling
with the immune response production, thus achieves the
suppression inflammation the function.Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate)
also may affect in the nerve cell membrane the ache
acceptor, has the shielding effect to the acceptor, may
alleviate the ache. |
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The source and the use
present situation of the HA |
Health care cosmetology food with
Hyaluronan from the cockscomb
extraction preparation, the purity request is generally
low, usually below 10%, includes the sulfuric acid chondroitin, the sulfuric acid skin element and the
collagen egg in addition waits in vain to compose the
extracellular matrix the material, called it compound
mounts the polysaccharide.Hyaluronan Mr is low, favors the
digestion absorption .
To one kind from cockscomb extraction named ECM?E (extracellular
matrix extraction thing) compound mounts the
polysaccharide the animal experiment and the human body
experiment proof, takes orally ECM?E may promote the
skin wound spot granulation tissue production and become
the ciliary cell the migration, has the obvious
promotion wound cicatrization function.The clinical test
result indicated that, takes orally ECM?E has the
obvious cosmetology effect.From d3~24, the most test
skin becomes smooth, the favor, the face, the hands and
feet as well as the whole body appears the cosmetology
effect. The cockscomb on enjoyed since old times as the
good food, EMC?E contains H-A, mounts the polysaccharide
and the protein and so on the natural material which has
for human body itself, has highly the security.The
cockscomb extraction protein content is high, after the
minority allergic physique person takes has the skin to
blush, sao itches and so on mild allergic reaction.If
has this kind of situation, should stop using . |
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Sodium Hyaluronate (Cosmetics,Eye drop,Injection,Feedstuff) Food Grade |
At the end of 1980s, the oral administration hyaluric acid
improves looks the health foods to
appear in Japan.Its basic theory basis is: The hyaluric
acid through the oral administration
after the digestion absorption, increases the precursor
which in vivo hyaluric acid
synthesizes, causes in the skin and other organization's hyaluric
acid the resultant quantity
increases, thus enables the skin the water retention
property to increase, rich elasticity, wrinkle
reduction.
The hyaluric acid the cosmetics only role Yu Tu to wipe
the spot the skin surface layer, increases the skin
surface the hyaluric acid (hyaluronic acid£¬Hyaluronan) the content,
plays moistens, guarantees the wet function, is topicality.But takes orally the hyaluric acid to improve looks the healthy product is the
body-wide function, is by the dermis to the epidermis
increase endocardial hyaluric acid (Sodium
Hyaluronate (Cosmetics,Eye drop,Injection,Feedstuff)
Food Grade) the
content, causes the cell to activate, plays the whole
body role, has the obvious difference with the cosmetics
partial use.The surface improves looks the main
consideration to partial epidermis nursing, but to does
not have the function as the skin main constituent
dermis.The dermis matrix mainly by the collogen and the
hyaluric acid (Sodium Hyaluronate (Cosmetics,Eye
drop,Injection,Feedstuff) Food Grade) and so on the mucopolysaccharides is composed, along with the age
growth, the skin aging is because the collogen has the
change to cause, but the collogen change is because has
guarantees the water function the
Hyaluronan (hyaluronic
acid) the reduced result.Therefore, the maintenance
collogen function must supplement the hyaluric acid. The
person the content is highest in the
embryo timein vivo hyaluric acid, after the birth
gradually decreases, if the
comparative content decides as 20 year-old humanbody in
hyaluric acid 100%, 30, 50, 60 year old of time-sharing
otherdrop is 65%, 45%, 25%. The same age crowd contains
the hyaluric acid (hyaluronic acid) the quantity is also
different, sicknesspatient's hyaluric acid (Sodium
Hyaluronate (Cosmetics,Eye drop,Injection,Feedstuff)
Food Grade) the content obviouslyreduces, demonstrates the
senile many symptoms. Takes orally the hyaluric acid (hyaluronic
acid) to improve looks the health foods to be allowed to
supplement in vivo the hyaluric acid has the activation
skin cell, the maintenanceepidermis is moist, improves
function and so on skin. The performance for by in vivo
to in vitro whole body cosmetology and the health
care,is valued more and more many people's and accepts.
Especially starts the regular supplement hyaluric acid
from more than 30 years old to be possible obviously to lengthen
the skin youth.
Except the skin outside, the
Hyaluronan also
similarly gets up in other organizations and the organ
the lubrication to guarantee the water and so on the
important physiological action, like ticulare, blood
vessel, heart, eye, brain and so on.In these
organizations hyaluric acid the content reduces may
cause arthritis, the arteriosclerosis, the pulse not not
neat, the eye aging, the atrophy of brain.The oral
administration hyaluric acid may supplement in vivo
hyaluric acid the insufficiency, the prevention gets
older, maintenance aging crowd's health. |
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The physiological function of
HA in skin |
1£®Keep the water
Hyaluronic Acid guarantees the water function in the
skin organization is one of its most important
physiological functions, Its theory guarantees water
number Above 500ml/g, contracts in the organization in
the knot the reality to guarantee the water number approximately.Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate,Sodium
Hyaluronate (Cosmetics,Eye drop,Injection,Feedstuff)
Food Grade) when high density, its long molecular
chain interweaves mutually the lattice, adds it with the
water hydrogen bond union, thus plays very strongly
guarantees the water role.Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) outside the butcher in the
matrix main function is The maintenance moisture
content, with other sulphating mucopolysaccharide and
the collogen, the elastic egg waits in vain the fibrous
protein, composes together including outside the massive
moisture content butcher the porodine matrix, becomes
the cell metabolism the material interchange medium.This
kind of watery porodine matrix, causes the skin to be
pliable but hard to break, the rich elasticity, the
sufficient moisture content causes the flesh smoothly
delicate.When skin moist feeling vanishing, appears the
wrinkle, some people thought is which causes as a result
of the Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) reduction.Along with the age growth, in the
skin the Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) content reduces, the skin organization cell
and the intercellular space moisture content reduces,
the space which by Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate,Sodium
Hyaluronate (Cosmetics,Eye drop,Injection,Feedstuff)
Food Grade) the intercellular space which
primarily composes the porodine matrix fills to reduce,
causes the cell arrangement to be close, the collogen
dehydration hardens, causes the skin to be rough, loses
the elasticity.Therefore the moisture content regarding
the skin health is very important. Guarantees Shui
Baoshi always is the skin care puts on make-up skin care
cosmetics) one of most main research topics, also is one
of skin appliances main functions.
2£®Maintenance extracellular spatial
Matrix ingredients and so on Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) and sulfuric acid chondroitin, sulfuric acid skin element and contain the
massive moisture contents, form the butcher outer space
together, is advantageous in the nutrients supply and
metabolism waste emissions, the epidermal cell
migration, the immune cell (the Langge rarely Si cell
and the lymph thin in dermis difference .
3.Large ion merit
On the Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) member chain each double sugar unit has a
negative charge (one C00¡¥), enable it to have the
similar ionic exchange medicinal preparation function,
around the adjustment cell the positive ion flowing and
the density .
4. Prticipation keratin cell change process
Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) in cuticular layer close participation keratin cell
multiplication, to outer layer migration and
differentiation and so on, adjustment entire change
process, but its itself metabolism hormone, growth
factor and cell activator (cytokinin) equisignal member
regulative [6,7].Regards the xanthognic acid (retinoic
acid) and the epidermis grows because of �?
epidermal growth factor, EGF) may stimulate
Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) the
biosynthesis, increases in the skin the Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) content, but
the hydrogenation may then pine's function opposite.Therefore, from the cosmetology and the
protection skin angle, the skin surface should little
use the adrenal cortex hormone class medicine as far as
possible .
5. Aceptor unions affects
A and epidermal cell surface CD44 acceptor union,
promotion epidermal cell normal differentiation.The CD44
acceptor is the epidermis normal growth and the split up
symbol, when the skin has the squamose cell cancer, the
keratin cell split up stop, falls off with the CD44
acceptor reduction and Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) from the cell surface concerns.Hyaluronic Acid(HA,Hyaluronan,Sodium Hyaluronate) is the cell survival signal material, it
with the keratin cell surface acceptor union, has one
kind of stimulation, can slow down to the cutin cell
differentiation which finally withers perishes .
6. Emination free radicals affect
Hyaluronic Acid£¨Hyaluronan,Sodium Hyaluronate (Cosmetics,Eye drop,Injection,Feedstuff)
Food Grade£© active oxygen soap in the epidermis
which in the sunlight the ultraviolet radiation
produces, by the base, protects the skin to exempt its
evil, is called the highly effective free radical the
street sweeper”.The oxygen free radical may cause
the lipin peroxidation, the destruction cell membrane,
the killing cell, and pigmentation concerns with skin.Hyaluronan
and the oxygen free radical has the response, the free
radical is eliminated, H-A is degraded.Therefore
Sodium Hyaluronate (Cosmetics,Eye drop,Injection,Feedstuff) Food Grade also
has guards against exposes to the sun the function. |
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Sodium Hyaluronate (Cosmetics,Eye drop,Injection,Feedstuff) Food Grade |
Sodium Hyaluronate (Cosmetics,Eye drop,Injection,Feedstuff) Food Grade is the sodium salt of hyaluronan. It is
a visco-elastic polymer normally found in the aqueous
and vitreous humour. Sodium Hyaluronate (Cosmetics,Eye drop,Injection,Feedstuff) Food Grade occurs naturally
on the corneal endothelium, bound to specific receptors.
Sodium hyaluronate has a high affinity for the
receptors.Brand Names include: Healon; AMO Vitrax;
Amvisic Plus; Hyalgan; Hylo-Comod (Eye Drop).
Therapeutic Category
Ophthalmic agent, Viscoelastic.
Mechanism of Action
Functions as a tissue lubricant and is thought to play
an important role in modulating the interactions between
adjacent tissues. Sodium Hyaluronate (Cosmetics,Eye drop,Injection,Feedstuff) Food Grade is a polysaccharide
which is distributed widely in the extracellular matrix
of connective tissue in man. It forms a Viscoelastic
solution in water which makes it suitable for aqueous
and vitreous humor in ophthalmic surgery. Mechanical
protection for tissues (iris, retina) and cell layers
(corneal, endothelium, and epithelium) are provided by
the high viscosity of the solution. Elasticity of the
solution assists in absorbing mechanical stress and
providing a protective buffer for tissues. This
viscoelasticity enables maintenance of a deep chamber
during surgical manipulation since the solution does not
flow out of the open anterior chamber. In facilitating
wound healing, it is thought that it acts as a
protective transport vehicle, taking peptide growth
factors and other structural proteins to a site of
action. It is then enzymatically degraded and active
proteins are released to promote tissue repair.Sodium Hyaluronate (Cosmetics,Eye drop,Injection,Feedstuff) Food Grade is being used intra-articularly to treat
osteoarthritis. To remain healthy, all cartilage,
regardless of type, needs the proteoglycans found in all
connective tissues to attract and maintain water
molecules; a collagenous mesh in which to bind the
proteoglycans; and plenty of water.
Use
Surgical aid in cataract extraction, intraocular
implantation, corneal transplant, glaucoma filtration,
and retinal attachment surgery; relief of mild to
moderate pain due to osteoarthritis of the knee. It also
used for treatment of dry eyes. |
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