Cosmetic Ingredients

HA Production

Sources of Hyaluronan(Hyaluronic Acid ,HA,Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings)

Vegetable Food Sources for Hyaluronate Hyaluronic Acid (HA,Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings

The Wonders of Hyaluronic Acid: Nature’s First Cosmeceutical by Dr. Dennis Gross

Cosmetic Ingredients

As we are learn more about our skin, the public is becoming more ingredient conscious. Understanding what substances make up a product can be helpful. If you have a known allergy, your dermatologist or allergist can help you determine other related ingredients. It will also help you to understand what makes a product greasy, irritating, acne-flaring, drying and hopefully those that are effective, too! This is not meant to be a complete list of every ingredient used in the industry, but will attempt to cover the most popular individual ingredients and categories that have gained recognition as of late. Use this as a handy reference by which to gain information as you learn more about your skin through our site. This list shall be continually expanded. The Fair Packaging and Labeling Act (FP&L) has set guidelines regulating ingredient listings. Listings begin with the ingredient present in the largest concentration (often times the necessary vehicles water or SD alcohol 40) and moves downward to often times trace elements. The vehicle is responsible to carry the other ingredients, creating the actual suspension, so just because water may potentially make up most of a product, it is usually for good reason. and etc.

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The Wonders of Hyaluronic Acid: Nature’s First Cosmeceutical by Dr. Dennis Gross

My dermatologic practice has clearly demonstrated to me that skin aging is not just a loss of collagen, but also a loss of water. It’s the loss of both that accounts for fine lines, deeper wrinkles, folds and even sagging of the skin as we age. Collagen, no doubt, is the primary structural protein giving skin its firmness. But, if collagen serves as the bricks in skin structure, then hyaluronic acid clearly serves as the mortar. A Hyaluronic Acid (Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings)is a natural constituent of skin and has the remarkable ability to hold nearly one thousand times its weight in water. That’s how H-A contributes to the thickness of skin: it doesn’t build like collagen, it inflates with water. H-A is also known as sodium hyaluronate and is a macromolecule officially classified in the chemical group known as a glycosaminoglycan. Collagen and H-A are, interestingly enough, both produced by the same dermal skin cells called fibroblasts. Born of the same mother cell, both collagen and HA (Hyaluronic Acid (Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) degenerate in human skin with aging and sun damage. Hormone depletion, lowered estrogen and menopause all cause the manufacturing of H-A to diminish. HA (Hyaluronic Acid (Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) is probably the most underrated and powerful ingredient the cosmaceutical industry has yet to fully exploit. It has been the focus of much of my own research. The key benefit and added beauty HA (Hyaluronic Acid Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) brings to skin is defined by the word turgid: the optimal plumpness of skin achieved by the retention of water. When skin is optimally turgid, it appears smoother and plumper. HA (Hyaluronic Acid(Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) achieves this effect because it is one of the most important regulators of water metabolism in the skin. To appreciate how it beautifies the skin, one must explore H-A’s different mechanisms of action on the epidermis and dermis. When applied directly to the epidermis via topical products, such as creams and gels,HA (Hyaluronic Acid (Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) hydrates the skin as a humectant. It literally attracts air born water vapor into the skin and retains water delivered to the skin by the circulation. Because of this mechanism, the dermatologic effect of moisturization is superior to what could be achieved by the typical moisturizer composed only of a routine oil- and-water mixture. HA (Hyaluronic Acid (Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) is a key ingredient that is fortunately highly soluble and adds another dimension to product design. The truth is that a moisturizer without a humectant only provides the skin with the additional water barely contained in that small amount of product one spreads over their skin. HA (Hyaluronic Acid (Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) also provides another key benefit by preventing the evaporation of water from the skin. Clinical research on dry skin measures a key index known as trans-epidermal water-loss (TEWL). Think of it as a measurement of the skin’s inability to retain water which is lost by evaporation. Studies clearly demonstrate that sun damaged skin take on its chronic dry skin appearance because of its associated increase TEWL. While this condition may also involve an abnormal lack of exfoliation, HA (Hyaluronic Acid (Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) should be a key therapeutic ingredient in one’s skincare regimen because humectants ordinarily synthesized by the skin are reduced as a consequence of sun damage. The skin’s natural HA (Hyaluronic Acid (Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) may also be lost by mistakes made in one’s cleansing routine. Whereas aging and sun damage reduce the skin’s ability to retain water, cleansing may strip the skin of its own humectants and oils beyond the skin’s ability to manufacture them. Generally, bar soap is more drying than non-soap liquid cleansers, and soapy liquid cleansers are often the most drying of all. Everyone knows when their skin is severely dry simply because it looks flaky. Educating your clients on how to prevent dryness is more challenging. Facial skin may be especially tricky to diagnose because it may be dry and yet show no flaking. Many people simply do not know whether their cleansing routine is right for them. And what’s right for you today may change with the seasons, your age or even with what other products you use. After years of practice, I have learned the best overall way to determine if someone is at risk of dryness is to simply ask whether their skin, especially their face, feels tight and uncomfortable thirty seconds after toweling dry. If the answer is yes, switching to a milder cleanser is recommended. Remember, the skin is an insensible organ, which means we are not aware of it unless something is wrong. After several episodes of feeling tight, true dryness and even irritation may result. Sometimes simply using less soap is sufficient (I constantly tell patients soap is not like shampoo so don’t lather up the same way) or simply changing from a scrub cleanser to a gentle one does the trick. Thus far we have focused on the role of HA (Hyaluronic Acid (Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) in the superficial epidermal portion of the skin where its chief function is to moisturize. But H-Ais also naturally found in the deeper dermal portion of the skin where its major role is to increase thickness (turgidity) by holding water. Unfortunately, applying HA (Hyaluronic Acid (Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) topically has its limitations because only a limited amount can penetrate.H-A is a thick viscous substance which feels sticky, even gummy, on the skin if overly concentrated in a topical product. So far the only solution the beauty industry has for getting H-A into the deeper skin is via injection administered by physicians. Although, as discussed below, my patented research indicates that there is yet another method to deliver H-A into deeper skin either via an esthetician or an at-home product. Injectible HA (Hyaluronic Acid (Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) is now a very popular procedure performed by dermatologists and plastic surgeons and is probably another contributing factor to the statistical decline of some plastic surgery procedures (such as brow lifts) performed in recent years. Commercially available forms of injectible HA (Hyaluronic Acid (Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) are sold as Restylane, Hylaform and Captique. Along with Botox injection, injectible  procedures have been increasing steadily in the U.S. since gaining FDA approval several years ago. HA(Hyaluronic Acid (Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) injected into the dermal skin acts as a filler to plump and elevate wrinkles, folds, and even depressed acne scars. The nasolabial fold is the most popular use of the material, although it may be used to plump any deeper defects in the face such as the perioral or brow areas. A thinner version of Restylane is available for fine lines such as the crow’s feet around the eyes. Injectible collagen (Zyderm and Zyplast) was the first synthetic filler approved by the FDA in the 1980s and is still widely used. In my experience, injectible HA ( Hyaluronic Acid (Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) does offer several advantages over its predecessor. Injectible HA(Hyaluronic Acid (Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) is more natural and hypoallergenic and unlike Zyderm and Zyplast does not require skin testing before treatments. Some newer versions of injectible collagen (Cosmoderm) are also hypoallergenic as they are derived from cadavers. A typical patient receiving Restylane is told to avoid taking any aspirin products or Vitamin E for at least three days prior to the procedure to avoid bruising.Upon entering the treatment room, topical anesthesia is applied for fifteen to twenty minutes to minimize the pain from the injection. Some mild pain is still usually felt from the procedure due to the depth of the injection. Multiple shots with a fine needle are used to fill the lines or grooves and the area is then massaged for several minutes to avoid lumping and assure a smooth correction. I find ice packs applied at the end reduces swelling (which is minimal) and reduces localized bruising that is still the number one risk of the procedure which can last several days. The correction is immediate making those who like instant gratification especially happy. How long do the results last? Most manufacturers advertise the benefits are seen for six months. In my experience this is generally true, although the improvement starts to decline after four months. My amazement with HA(Hyaluronic Acid (Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) motivated me to conduct my own research through my company MD Skincare. The central issue, you now understand, is this: applied topically to the epidermis  works as a great moisturizer but for it to plump it must be injected into the dermis. Could another delivery system be developed that gives HA(Hyaluronic Acid (Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) better penetration, without injecting it, allowing it to both hydrate and firm skin? The answer is yes, and here is what I discovered. A thick gel of concentrated  can be applied to the face and massaged in with water. Because all ingredients have deeper penetration when under occlusion such as a bandage, I find using a mask over HA( Hyaluronic Acid (Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) similarly deepens its penetration exceptionally well. Furthermore, if the mask is self-heating then it will also bring a burst of blood flow to the skin which contains additional water from the circulatory system. By simple osmosis the water is attracted to the which clings to it at a rate of one thousand times its weight. Because the HA(Hyaluronic Acid (Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) is deeper in the skin when the water appears, H-A not only moisturizes but also acts as a filler to plump and firm the skin. The plumping-effect is dramatic and, although less than if injected, can be achieved by the hands of an esthetician or with an at-home product. In summary, HA(Hyaluronic Acid (Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) is the wonder drug nature has to offer and is a star in the cosmeceutical industry. Few ingredients are as safe, versatile and effective. A natural constituent of skin itself, when combined with laboratory technology HA(Hyaluronic Acid (Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) enhances moisture and plumps skin. It’s the newly discovered long lost cousin to collagen, and partner to another ingredient fundamental to beauty and life itself: water! About the Author: Dr. Gross received his degree in medicine and then completed his dermatological residency at New York University Medical Center. He is Board Certified in both Dermatology and Dermatologic Surgery, as well a nationally recognized skin care pioneer. An innovator in dermatologic research at Memorial Sloan Kettering Institute, The Rockefeller Institute and New York University Medical Center, his knowledge and experience have led to his authoring numerous publications, as well as his being a key participant in the dermatological professional associations. Dr. Gross is the founder of MD- Skincare.

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HA Production

Hyaluronic acid (also called Hyaluronan or HA) is an element of the connective tissue that acts as a cushion and lubricate. Hyaluronan (Hyaluronic Acid,HA,sodium hyaluronate)occurs in copious amounts throughout the body, especially in places where people with hereditary connective tissue disorders have problems, such as joints, heart valves and eyes. Hyaluronic acid abnormalities are a common thread in connective tissue disorders. There are also common biochemical deviations in most of the individual features of connective tissue disorders such as mitral valve prolapse, TMJ, osteoarthritis, and keratoconus. Hyaluronic Acid is present in every tissue of the body. Retention of water is one of the most important biological functions of Hyaluronic acid (HA,Hyaluronan,sodium hyaluronate). It is also critical in providing nutrients and removing waste from cells that do not have a direct blood supply, such as cartilage cells. If the amount of Hyaluronic acid    (HA,Hyaluronan,sodium hyaluronate) depletes, nutrients cannot be moved into these cells and waste cannot be eliminated from cells.H-A is found in the synovial joint fluid, the vitreous humor of the eye, the cartilage, blood vessels, extracellular matrix, skin and the umbilical cord. Hyaluronic acid ((HA,Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) has been nicknamed the "key to the fountain of youth" because it has been noted that some people who ingest a lot of H-A in their diets tend to live longer. Some Japanese villagers have been known to live to ripe old ages due to the use of HA Hyaluronic acid for use by humans is derived from rooster combs, which provide the purest form of Hyaluronic acid ((HA,Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) available. Hyaluronic Acid (HA,Hyaluronan,sodium hyaluronate) Benefits • moisturizes skin from the inside out, smoothing out wrinkles in the process • helps people who need to ease the flexing of their joints, especially their knees, by restoring cushioning to their joints • suitable for men and women in their 30s and 40s who are beginning to see the first signs of aging • suitable for seniors who have established joint conditions

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Sources of Hyaluronan

Since the beginning of time, people have been searching for an effective way to reverse the aging process. H-A is seen by many to be the Fountain of Youth, and there are plenty of natural sources available to make it part of a healthy diet. Hyaluronic Acid (HA,Hyaluronan,sodium hyaluronate) Facts H-A is found in the connective tissues of humans and animals. It plays a key role in cushioning and lubricating the body and is abundant in the eyes, joints and heart valves. A powerful antioxidant, H-A is perhaps best known for its ability to bond water to tissue. Hyaluronic Acid (HA,Hyaluronan,sodium hyaluronate) Benefits The body's hyaluro-nic acid  levels decrease with age. In theory, sustaining optimal Hyaluronic acid levels could retard the aging process, prolong a youthful appearance, and sustain life. A prominent component in synovial fluid,  helps lubricate the joints and fight arthritis. It can be taken in capsule form or injected directly into the joints to relieve pain, helping even old bones feel young. Hyaluronic acid ((HA,Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings), with its remarkable ability to keep tissue moist, is particularly effective in treating wrinkles and dry skin. It maintains skin elasticity and even speeds up the healing process for wounds and scars.  is also believed to promote healthy eyes and heart valve function. Hyaluronic Acid (HA,Hyaluronan,sodium hyaluronate) Sources Since HA is found in the connective tissue of animals, consuming animal products is believed to be the best natural source available. Chicken soup made from boiling the bones and skin of chickens can be a surprisingly rich source for hyaluronic acid. Even most hyaluronic acid supplements are made from rooster combs. Other options exist for vegetarians. Magnesium is needed in the body to synthesize Hyaluronic acid, so consuming foods rich in magnesium, like avocados, broccoli, peanuts, potatoes, soy and spinach can keep Hyaluronic acid levels from dropping too low. Estrogen and Hyaluronic acid (HA,Hyaluronan,sodium hyaluronate) have somewhat of a symbiotic relationship. When the level of one rises, so does the level of the other. Soy products, like tofu and soy beans, have been shown to increase estrogen levels, making them an indirect source for hyaluronic acid. Zinc deficiencies seem to coincide with low Hyaluronic acid. Consuming brown rice, peanuts, potatoes, pumpkin seeds and other zinc-rich foods could alleviate the problem. Hyaluronic Acid (HA,Hyaluronan,sodium hyaluronate) Geography Yazuri Hara, a small village in Japan, is known for its youthful citizens who live well into their 80s and 90s with virtually no wrinkles and few health complaints. Studies have indicated they have naturally high levels of H-A due to diets rich in starchy root vegetables like sweet potatoes and other local forms of potato roots. Hyaluronic Acid (HA,Hyaluronan,sodium hyaluronate) Warnings Researchers at the University of California San Francisco have discovered abnormally high levels of Hyaluronic acid could contribute to tumor progression in breast cancer. The University of Minnesota's Department of Surgery has found similar results regarding colon cancer.

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Vegetable Food Sources for Hyaluronate

Hyaluronic acid (HA,Hyaluronan,sodium hyaluronate) is a naturally occurring chemical created by the body that provides cushioning for joints and connective tissues. Individuals with insufficient amounts of Hyaluronic acid (HA,Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) may experience issues with osteoarthritis, TMJ, detached retinas, poor scar formation, wrinkles, fibromyalgia, glaucoma or heart valves. H-A is mostly found in animals, though there are a variety of non-meat options that can help increase hyaluronic acid ( (HA,Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings)production in the body. Soy Because of its tendency to increase levels of estrogen in the body--which in turn increases levels of hyaluronic acid--soy is a great vegetable option. Soy beans in their original baby form are edamame. Tofu, or soy bean curd, is the most versatile soy food. Soy milk, soy ice cream or soy yogurt are a few other options. Soy can also be found as textured vegetable protein. Magnesium Magnesium is essential for Hyaluronic acid ((HA,Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) synthesis; a lack of magnesium in the diet may be part of the cause of low Hyaluronic acid levels. Soy is rich in magnesium, as is spinach, green beans, broccoli, cauliflower, asparagus, potatoes, green lettuce and carrots. A variety of magnesium-rich fruits are available: apples, bananas, strawberries, tomatoes, avocados, pineapples, oranges, papayas, melons, peaches and pears. Legumes such as kidney beans, pinto beans, black-eyed peas and lentils are rich in magnesium. Peanuts and almonds also contain magnesium. Zinc Low levels of Hyaluronic acid ((HA,Hyaluronan,sodium hyaluronate):Facts,Benefits,Sources,Geography,Warnings) has also been found in individuals with low zinc levels. Zinc is utilized for a variety of bodily processes. Usually associated with foods rich in protein, such as beef, lamb, pork or chicken, there are a few non-meat options. The best vegetable source for zinc is pumpkin seeds. Potatoes are also a good source, as is yeast, peanuts, beans, whole grains or brown rice.

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